Clinical Evaluation of Leech Therapy in the Treatment of Knee Osteoarthritis

Jamia Hamdard0 个研究点目标入组 60 人开始时间: 待定最近更新: 2021年11月24日

试验速览

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•Individuals > 40 yrs, either sex
•Diagnosed as OA of the knee of at least 6 months duration fulfilling American College of Rheumatology criteria
•Knee pain VAS- pain after walking 1,524 cm (50 feet) in a flat surface >30 mm and <90 mm
•Kellgren-Lawrence Radiographic Grading Scale of Osteoarthritis of the Tibiofemoral Joint Grade 1â?? 3
•Patients who were willing to discontinue all NSAIDs or other analgesic medication taken for any condition
•Patients who had given their written informed consent & agreed to follow the protocol voluntarily

•Pregnancy and Lactation
•Anemia ( <10 g% Hb) and Bleeding disorders
•Diabetes mellitus
•Patients who were on steroid drug therapy
•History of surgery of the joint involved, Tidal lavage or arthroscopy of either knee within the past 12 months
•Hypersensitivity/ allergy to food &/ drug or leech
•Intra-articular (IA) corticosteroid injection of either knee within a 3 month interval immediately prior to baseline screening
•Acute medical or surgical conditions which could affect the outcome of the study such as cardiac, renal, hepatic diseases.
•Patients who were using anti-coagulants (coumadin, heparin, aspirin >325 mg per day).
•Patients were not willing to be randomized
•Ongoing use of prohibited medication including NSAID, other oral analgesic, muscle relaxant, or low-dose antidepressant for any chronic pain management
•Concomitant skin disease at the application site
•History of alcohol or Drug abuse, excessive smoking (more than 10 cigarettes/day)
•Established/ diagnosed neurological or psychiatric disorders

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