on-irritative concentrations for drug allergy skin tests

Completed

• Conditions: drug allergy; drug hypersensitivity; 10001708

• Registration Number: NL-OMON40331
• Lead Sponsor: Academisch Medisch Centrum

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 29 April 2024

Recruitment & Eligibility

• Status: Completed
• Sex: Not specified
• Target Recruitment: 66

Inclusion Criteria

- absence of significant disease
- age * 18 year, * 50 year
- signed informed consent

Exclusion Criteria

- Age < 18 year or > 50 year
- Previous general anaesthesia, with the exception of (adeno)tonsillectomie before 2000
- History of drug hypersensitivity
- History of anaphylaxis
- History of seasonal or perennial rhinoconjunctivitis
- Use of antihistamines, corticosteroids, immunosuppressant drugs
- Positive dermographism

Study & Design

• Study Type: Observational invasive
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>The maximal concentration of drugs generally used in anaesthesiology that can<br /><br>be used for intradermal skin tests without eliciting an aspecific (irritative)<br /><br>response reaction. </p><br>

Secondary Outcome Measures

Name	Time	Method
<p>The percentage/number of positive tests of each drug at each concentration as<br /><br>judged by two different criteria (ENDA and SFAR).</p><br>