Minocycline's Effects on Alcohol Responses in Humans
- Conditions
- Alcohol Dependence
- Interventions
- Drug: Placebo (for Minocycline)Drug: Minocycline
- Registration Number
- NCT02187211
- Lead Sponsor
- Yale University
- Brief Summary
This is a double-blind, placebo-controlled, outpatient study with a between-groups design. Sixty male and female heavy social drinkers will be randomly assigned to minocycline (200 or 400 mg/day) or placebo for 10 days. In the first 7 days of treatment, subjects will have 3 outpatient visits for medication administration, dispensing of take-home doses and monitoring of any adverse effects from study medications. On days 8 and 10 of treatment, subjects will have 2 laboratory sessions where alcohol or placebo will be administered intravenously using a clamp procedure. Alcohol administration will use a breath alcohol concentration (BrAc) method, targeting 100 mg %. The alcohol clamp procedure will allow collection of multiple outcome measures including subjective, motor, cognitive measurement and plasma cytokine levels.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 54
- Male and females, between the ages of 21 and 50;
- Heavy social drinkers who are defined as consuming ≥10 standard alcoholic drinks per week with one to five weekly "binge" drinking episodes, (5 plus drinks per occasion for men; 4 plus drinks for women). No maximum level of alcohol consumption will be defined a priori but individuals who met current DSM -IV criteria for AUD will be excluded from the study;
- No current drug use disorder of any drugs of abuse (except alcohol and tobacco);
- No current medical problems and normal ECG; 5) For women, not pregnant as determined by pregnancy screening nor breast feeding, and using acceptable birth control methods.
- Current major psychiatric illnesses including mood, psychotic, or anxiety disorders;
- History of major medical illnesses; including liver diseases, heart disease, chronic pain or other medical conditions that the physician investigator deems contraindicated for the subject to be in the study;
- Liver function tests (ALT or AST) greater than 3 times normal;
- Allergy to minocycline or other tetracyclines;
- Participants who at any appointment have a Clinical Institute Withdrawal Assessment Scale (CIWA) [36, 37] score of 4 or greater, or who report any history of alcohol withdrawal within the past 6 months.
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- CROSSOVER
- Arm && Interventions
Group Intervention Description Placebo Placebo (for Minocycline) Participants in this arm will receive the Placebo for 10 days Minocycline Low Dose Minocycline Participants in this arm will receive a low dose (200mg/day) of Minocycline for 10 days Minocycline High Dose Minocycline Participants in this arm will receive a high dose (400mg/day) of Minocycline for 10 days
- Primary Outcome Measures
Name Time Method Biphasic Alcohol Effects Scale (BAES) Days 1-10 BAES will be used to measure the stimulant and sedative effects of alcohol during the test sessions. This instrument has been found to be a sensitive and reliable measure to study medication influences on alcohol effects
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
VA Connecticut Healthcare System
🇺🇸West Haven, Connecticut, United States