Changes in Attentional Control After a Focal Seizure.

Recruiting

• Conditions: Temporal Lobe Epilepsy; Others Subtypes; Frontal Lobe Epilepsy

• Registration Number: NCT06466681
• Lead Sponsor: University Hospital, Lille

Brief Summary

Epilepsy is frequently associated with cognitive and attentional disorders. Several studies have pointed out that there are modifications of brain activity in resting state during peri-ictal period in EEG and functional MRI. However, to date, no study has assessed the changes in attentional control after a seizure. The investigators hypothesize that a localized discharge is associated with a disorganization of the networks engaged in attentional control. In this regard, the investigators propose a prospective longitudinal study assessing the changes in attentional control after a focal seizure.

Detailed Description

Not available

Study Timeline

• Study Start: 2024-03-04
• Study First Submitted: 2024-05-21
• Study First Submitted QC: 2024-06-13
• Study First Posted: 2024-06-20
• Status Verified: 2025-05
• Last Update Submitted: 2025-05-12
• Last Update Posted: 2025-05-13
• Primary Completion: 2027-03-09
• Study Completion: 2027-03-09

Recruitment & Eligibility

• Status: RECRUITING
• Sex: All
• Target Recruitment: 100

Inclusion Criteria

• Age superior to 18 and under 80
• Focal epilepsy with indication to pre-surgery work-up and 5 days programmed hospitalization dedicated to this work-up
• Normal global cognitive performance (standard progressive Raven matrices score > 5th percentile)
• Be affiliated to the social security system
• Have signed an informed consent

Exclusion Criteria

• Pregnancy or breastfeeding
• Not able to give consent (Article 1121-8 of the CSP)
• Vulnerable person
• Being deprived of liberty by judicial or administrative decision (Article L 1121-6 of the CSP)
• Guardianship
• Have a high probability of not respecting the protocol or of abandoning the study
• Absence of any epileptic seizure recorded during the hospitalization
• Recurrent seizures preventing the recording of at least 24 hours without any seizure following a seizure.

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Subtest of divided attention of the Test of Attentional Performance (TAP)	24 hours	A first time during interictal period (no seizure for more than 24 hours) (this first measure will be repeated every day until a seizure is recorded) and 1, 3, 6 and 24 hours after a focal seizure.

Secondary Outcome Measures

Name	Time	Method
P300 amplitude and latency	24 hours	A first time during interictal period (no seizure for more than 24 hours) (this first measure will be repeated every days until a seizure is recorded) and 1, 3, 6 and 24 hours after a focal seizure.
Differences in strength of EEG functional connectivity during an attentional task recorded between different subgroups according to the epileptic focus.	24 hours
Strength of EEG functionnal connectivity during an attentional task (global and regional)	24 hours	A first time during interictal period (no seizure for more than 24 hours) (this first measure will be repeated every days until a seizure is recorded) and 1, 3, 6 and 24 hours after a focal seizure.
Magnetic resonance imaging functional connectivity.	up to 5 days
Differences in variation of power in several frequency bands (theta, alpha and beta) during an attentional task recorded between different subgroups according to the epileptic focus.	24 hours
Variation of power in several frequency bands (theta, alpha and beta) during an attentional task.	24 hours	A first time during interictal period (no seizure for more than 24 hours) (this first measure will be repeated every day until a seizure is recorded) and 1, 3, 6 and 24 hours after a focal seizure.
Differences in N200 and P300 amplitude and latency recorded between different subgroups according to the epileptic focus.	24 hours	A first time during interictal period (no seizure for more than 24 hours) (this first measure will be repeated every day until a seizure is recorded) and 1, 3, 6 and 24 hours after a focal seizure.
N200 amplitude and latency	24 hours	A first time during interictal period (no seizure for more than 24 hours) (this first measure will be repeated every days until a seizure is recorded) and 1, 3, 6 and 24 hours after a focal seizure.
Differences in magnetic resonance imaging functional connectivity recorded between different subgroups according to the epileptic focus.	24 hours

Trial Locations

Locations (1)

University Hospital,; 🇫🇷 Lille, France