Acceleration of Recovery From General Anesthesia - Efficacy of Isocapnic Hyperpnoea in Obese Patients Undergoing Isoflurane Anesthesia

Not Applicable

Completed

• Conditions: Recovery Time From Isoflurane Anesthesia in Obese Patients
• Interventions: Other: Isocapnic Hyperpnoea

• Registration Number: NCT00752492
• Lead Sponsor: University Health Network, Toronto

Brief Summary

Faster recovery from anesthesia is important for obese patients because they are at high risk of respiratory complications following tracheal extubation. Isoflurane has several properties that make it a preferable agent for anesthesia in obese patients. Its main limitation is a longer recovery time due to slower elimination in comparison to other agents. Elimination of isoflurane from the lungs can be accelerated by increasing in patient's minute ventilation, which decreases the level of CO2 in blood (hypocapnia).Isocapnic Hyperpnoea (IH) is a method allowing increased ventilation and therefore enhancement of the elimination of inhalation agents while maintaining a normal blood CO2 level. The investigators will compare recovery time from isoflurane anesthesia in obese patients during standard anesthesia management protocol (control) to a group treated with IH.

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2008-07-22
• Study Start: 2008-09
• Study First Submitted QC: 2008-09-12
• Study First Posted: 2008-09-15
• Primary Completion: 2010-06
• Status Verified: 2011-04
• Study Completion: 2011-04
• Last Update Submitted: 2011-04-19
• Last Update Posted: 2011-04-20

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 44

Inclusion Criteria

Elective gynecological or urological procedure,

• BMI > 35 kg/m²,
• ASA I-III,
• Signed informed consent.

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Exclusion Criteria

• Lack of informed consent,
• ASA IV-V,
• Contra-indications to isoflurane anesthesia or other anesthetics included in the protocol,
• History of cardiac or respiratory disease,
• Alcohol or drug abuse,
• Psychiatric illness and/or medications.

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Study & Design

• Study Type: INTERVENTIONAL
• Study Design: SINGLE_GROUP

Arm && Interventions

Group	Intervention	Description
Study intervention	Isocapnic Hyperpnoea	Patient will be disconnected from the anesthetic circuit and connected to the resuscitation bag attached to the IH system. Ventilation will be assisted to maintain tidal volume of 8-10 mL/kg and respiratory rate of 20-25 breaths per minute to achieve minute ventilation of 15-20 L/min. Isocapnia manifold will maintain end-tidal PCO2 in range of 40-50 mm Hg.

Primary Outcome Measures

Name	Time	Method
Time from the end of anesthesia (turning isoflurane vaporizer off) to the readiness for Post Anesthesia Care Unit (PACU) discharge.	Intraoperatively and Post Anesthetic Care Unit

Secondary Outcome Measures

Name	Time	Method
Times from end of anesthesia to BIS exceeds 75, b) eye-opening to verbal command, c) extubation, d) readiness for leaving	Intraoperatively and Post Anesthetic Care Unit
Sedation/Pain scores in the PACU.	Intraoperatively and Post Anesthetic Care Unit
Change in exhaled isoflurane concentrations in the 1st hour postoperatively.	Intraoperatively and Post Anesthetic Care Unit

Trial Locations

Locations (1)

Toronto General Hospital; 🇨🇦 Toronto, Ontario, Canada