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临床试验/NCT00752492
NCT00752492已完成不适用

Acceleration of Recovery From General Anesthesia - Efficacy of Isocapnic Hyperpnoea in Obese Patients Undergoing Isoflurane Anesthesia

University Health Network, Toronto2 个研究点 分布在 1 个国家目标入组 44 人开始时间: 2008年9月最近更新:
适应症

试验速览

阶段
不适用
状态
已完成
入组人数
44
试验地点
2
主要终点
Time from the end of anesthesia (turning isoflurane vaporizer off) to the readiness for Post Anesthesia Care Unit (PACU) discharge.

研究概览

简要总结

Faster recovery from anesthesia is important for obese patients because they are at high risk of respiratory complications following tracheal extubation. Isoflurane has several properties that make it a preferable agent for anesthesia in obese patients. Its main limitation is a longer recovery time due to slower elimination in comparison to other agents. Elimination of isoflurane from the lungs can be accelerated by increasing in patient's minute ventilation, which decreases the level of CO2 in blood (hypocapnia).Isocapnic Hyperpnoea (IH) is a method allowing increased ventilation and therefore enhancement of the elimination of inhalation agents while maintaining a normal blood CO2 level. The investigators will compare recovery time from isoflurane anesthesia in obese patients during standard anesthesia management protocol (control) to a group treated with IH.

研究设计

研究类型
Interventional
分配方式
Randomized
干预模型
Single Group
主要目的
Treatment
盲法
Single (Participant)

入排标准

年龄范围
18 Years 至 80 Years(Adult, Older Adult)
性别
All
接受健康志愿者

入选标准

  • Elective gynecological or urological procedure,
  • BMI > 35 kg/m²,
  • ASA I-III,
  • Signed informed consent.

排除标准

  • Lack of informed consent,
  • ASA IV-V,
  • Contra-indications to isoflurane anesthesia or other anesthetics included in the protocol,
  • History of cardiac or respiratory disease,
  • Alcohol or drug abuse,
  • Psychiatric illness and/or medications.

结局指标

主要结局

Time from the end of anesthesia (turning isoflurane vaporizer off) to the readiness for Post Anesthesia Care Unit (PACU) discharge.

时间窗: Intraoperatively and Post Anesthetic Care Unit

次要结局

  • Times from end of anesthesia to BIS exceeds 75, b) eye-opening to verbal command, c) extubation, d) readiness for leaving(Intraoperatively and Post Anesthetic Care Unit)
  • Sedation/Pain scores in the PACU.(Intraoperatively and Post Anesthetic Care Unit)
  • Change in exhaled isoflurane concentrations in the 1st hour postoperatively.(Intraoperatively and Post Anesthetic Care Unit)

研究者

申办方类型
Other

研究点 (2)

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