Correlation of adverse prognostic factors with survival outcomes in paediatric Precursor-B Lymphoblastic Leukemias: a single centre experience

Successful treatment of paediatric Precursor-B Lymphoblastic Leukemias (B-LBL) relies on assigning patients to appropriate risk groups. Modern protocols use a combination of age, white cell count (WCC), CNS involvement, immunophenotype, genetics and treatment response to assign patients to different treatment pathways which determines chemo-intensity, randomisations offered and eligibility for transplant or CAR-T. The primary aim of this retrospective observational study is to study the prognostic factors in B-LBLs on the basis of age, TLC, baseline immunophenotype, ploidy status, genetic features and CNS disease and classify them into standard and high risk subtypes and to study their correlation with EOI MRD status and survival outcomes (3 year-RFS and OS). This study will involve approximately 800 newly diagnosed adult (<15 years) patients of B-LBL. This will help in understanding the prognostic impact of the immunophenotypic patterns and the genetic profile of our BLBL patients, and may guide in deciding the targeted chemotherapy in selected cases.