Comparison of I-124 PET/CT, F-18 FDG PET/CT and I-123 Whole Body Scintigraphy for Recurrent Thyroid Cancer Detection
试验速览
- 阶段
- 不适用
- 状态
- 撤回
研究概览
简要总结
The management of thyroid cancer patients with suspicion of recurrent disease based on rising/detectable levels of thyroglobulin (Tg) involves imaging with iodine-123 whole body scintigraphy (I-123 WBS) and F-18 FDG PET/CT. However, the disease is not always detected. The use of another iodine isotope (I-124) with positron emitting characteristics for PET/CT may allow better identification of recurrent disease, thus allowing for more patients to be treated with I-131 as a curative attempt.
详细描述
The management of thyroid cancer patients with suspicion of recurrent disease based on rising/detectable levels of thyroglobulin (Tg) involves imaging with iodine-123 whole body scintigraphy (I-123 WBS) and F-18 FDG PET/CT. However, the disease is not always detected. The use of another iodine isotope (I-124) with positron emitting characteristics for PET/CT may allow better identification of recurrent disease, thus allowing for more patients to be treated with I-131 as a curative attempt.
Conducting this study we hope to find whether I-124 PET/CT allows for detection of more lesions in patients with suspected recurrent thyroid cancer than the current standard of care represented by I-123 WBS and F-18 FDG PET/CT.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patient at Nuclear Medicine clinic at Stanford University Medical Center
- •Treated thyroid cancer.
- •Detectable levels of Tg.
- •Referred for I-123 WBS and F-18 FDG PET/CT for detection of recurrent thyroid cancer.
- •Able to have a I-124 PET/CT the day after I-123 WBS and F-18 FDG PET/CT
- •Patients older than 18-year-old.
- •Patients with history of treated thyroid cancer and suspected recurrent thyroid cancer based on detectable levels of Tg.
- •Patients must have I-123 WBS and F-18 FDG PET/CT performed prior to the I-124 PET/CT.
- •Patients must understand and voluntarily sign an Informed Consent form after the contents have been fully explained to them.
排除标准
- •Patients who are not eligible for I-123 WBS and F-18 FDG PET/CT.
- •Patients who cannot complete I-123 WBS and F-18 FDG PET/CT.
- •Pregnant women.
- •Healthy volunteers.
- •Patients participating in other research studies.