fMRI Cholinergic Mechanisms in Schizophrenia

Completed

• Conditions: Schizophrenia

• Registration Number: NCT01191827
• Lead Sponsor: US Department of Veterans Affairs

Brief Summary

This study aims to determine how clozapine treatment improves neuronal measures of sensory gating in subjects with schizophrenia.

Detailed Description

This study will use functional magnetic resonance imaging (fMRI) to study patients treated with risperidone, a commonly used neuroleptic that does not improves sensory gating, to those treated with clozapine to determine which brain areas are involved in clozapine's normalization of sensory gating in schizophrenia.

Study Timeline

• Study Start: 2008-10
• Study First Submitted: 2010-08-27
• Study First Submitted QC: 2010-08-27
• Study First Posted: 2010-08-31
• Primary Completion: 2011-12
• Study Completion: 2011-12
• Results First Submitted: 2014-12-23
• Status Verified: 2015-05
• Results First Submitted QC: 2015-05-12
• Last Update Submitted: 2015-05-12
• Results First Posted: 2015-05-15
• Last Update Posted: 2015-05-15

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 40

Inclusion Criteria

• Diagnosis of schizophrenia
• age 18-60 yrs

Exclusion Criteria

• claustrophobia
• weight > 250 lbs
• metal in body other than dental fillings

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Neuronal Response During Sensory Gating	Immediate	Neuronal response (blood oxygenation level dependent functional magnetic resonance imaging signal, relative to the global mean) during sensory gating. Sensory gating is defined as the process of filtering out unnecessary environmental stimuli.

Trial Locations

Locations (1)

VA Eastern Colorado Health Care System, Denver; 🇺🇸 Denver, Colorado, United States