Integration of Homeostatic Signaling and Food Reward Processing in the Human Brain
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 23
- 主要终点
- Experimental fMRI task (incentive delay task)
研究概览
简要总结
The aim of this study is to investigate the influence of different metabolic states and hormonal satiety signalling on responses in neural reward networks.
详细描述
Given the rapid development of obesity world-wide, a better understanding of the interaction between the encoding of food reward in mesocorticolimbic reward pathways and homeostatic energy regulation is of paramount importance for the development of new treatment strategies. Healthy participants will undergo functional magnetic resonance imaging while performing a task distinguishing between the anticipation and the receipt of either food or monetary reward. Every participant will be scanned twice in a counterbalanced fashion, both during a state of hunger (after 24-hours fasting) and satiety. Blood samples will be collected to assess hormonal satiety signalling. We hope to provide new insights into the neurobiological underpinnings of motivational processing and hedonic evaluation of food reward.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Cross Sectional
入排标准
- 年龄范围
- 18 Years 至 45 Years（Adult）
- 性别
- Female
- 接受健康志愿者
- 是
入选标准
- •BMI <25 kg/m² and >18.5 kg/m²
- •no lifetime or current medical illness that could potentially affect appetite or body weight
- •right-handedness
- •normal or corrected-to-normal vision
排除标准
- •history of head injury or surgery
- •history of neurological disorder
- •severe psychiatric disorder (psychosis, bipolar disorder, substance abuse)
- •borderline personality disorder
- •current psychotropic medication
- •inability to undergo fMRI scanning (e.g. metallic implants, claustrophobia, Pacemakers)
- •pregnancy
结局指标
主要结局
Experimental fMRI task (incentive delay task)
时间窗: 22 min.
Participants were expecting food and monetary related reward, after a correct response to a simple task they received either food or monetary related reward.
Resting state brain activity using functional magnetic resonance imaging
时间窗: 5 min.
Functional brain imaging will be employed to assess functional connectivity in reward related brain networks.
次要结局
- Analysis of hormonal satiety signaling(30 min. before scanning)
- Self-report questionnaire regarding eating behavior (Dutch Eating Behavior Questionnaire)(30 min.)
研究者
Joe Simon
Principal Investigator
University of Heidelberg Medical Center