Invivo comparison between Patelet Rich Fibrin and Platelet Rich Fibrin with Corticosteroid following Mandibular third molar extraction
试验速览
- 阶段
- 4 期
- 状态
- 尚未招募
- 发起方
- 入组人数
- 50
- 试验地点
- 1
- 主要终点
- The reduction of pain, swelling and soft tissue healing will be seen in the PRF with corticosteroid group.
研究概览
简要总结
This interventional, prospective, randomized controlled trial is designed to evaluate and compare the clinical effectiveness of Platelet Rich Fibrin (PRF) and Platelet Rich Fibrin combined with corticosteroid in patients undergoing surgical extraction of impacted mandibular third molars.
A total of 50 patients meeting the inclusion and exclusion criteria will be recruited from the Department of Oral and Maxillofacial Surgery, Tagore Dental College and Hospital. Participants will be randomly assigned into two groups:
Group A: Extraction socket filled with PRF alone
Group B: Extraction socket filled with PRF mixed with corticosteroid gel
Postoperative outcomes including pain, swelling, and wound healing will be assessed on the 1st, 3rd, and 7th postoperative days. Pain will be measured using the Visual Analogue Scale (VAS), while swelling will be evaluated using three-line facial measurements.
The study aims to determine whether the addition of corticosteroid to PRF provides superior pain relief, better wound healing, and reduced postoperative swelling compared to PRF alone.
研究设计
- 研究类型
- Interventional
- 分配方式
- Coin toss, Lottery, toss of dice, shuffling cards etc
- 盲法
- None
入排标准
- 年龄范围
- 18.00 Year(s) 至 60.00 Year(s)（—）
- 性别
- All
入选标准
- •1.Patients should be greater than 18 years of age.
- •2.Patient with impacted third molar(vertical,mesioangular,distoangular,horizontal) requiring extraction or surgical removal.
排除标准
- •1.Patients having periapical pathologies or local tooth related pathologies.
- •2.Patients having any systemic diseases.
- •3.Patients with habits like smoking and alcohol consumption.
- •4.Patients who are not willing to participate in this study and will not provide informed consent.
结局指标
主要结局
The reduction of pain, swelling and soft tissue healing will be seen in the PRF with corticosteroid group.
时间窗: 1ST DAY,3RD DAY,7TH DAY POSTOPERATIVELY
次要结局
- The reduction of pain, swelling and soft tissue healing will be seen in the PRF with corticosteroid group.
研究者
Initha K
Tagore Dental College and Hospital