GLP-1's Effect on Cardiac Parameters and Mesenteric Blood Flow

Not Applicable

• Conditions: Healthy
• Interventions: Other: 1,5 nmol/kg,GLP-1 sc injection; Other: 1,5 nmol/kg GLP-1 9-36amide, sc injection; Other: Exendin-4 ;10 ug,sc injection; Other: saline

• Registration Number: NCT01988545
• Lead Sponsor: Zealand University Hospital

Brief Summary

to investigate the effect of the human incretin hormone GLP-1 on mesenteric blood flow and cardiac parameters

Detailed Description

to investigate the effect of the human incretin hormone GLP-1 on mesenteric blood flow and cardiac parameters, in healthy subjects, 4 arms, task force monitor

Study Timeline

• Status Verified: 2013-11
• Study Start: 2013-11
• Study First Submitted: 2013-11-13
• Study First Submitted QC: 2013-11-19
• Last Update Submitted: 2013-11-19
• Study First Posted: 2013-11-20
• Last Update Posted: 2013-11-20
• Primary Completion: 2014-06
• Study Completion: 2014-12

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 8

Inclusion Criteria

• healthy subjects

Exclusion Criteria

• medical conditions

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: SINGLE_GROUP

Arm && Interventions

Group	Intervention	Description
GLP-1 9-36amide	1,5 nmol/kg,GLP-1 sc injection	1,5 nmol/kg GLP-1 9-36amide, sc injection
GLP-1	1,5 nmol/kg GLP-1 9-36amide, sc injection	1,5 nmol/kg,GLP-1 sc injection
GLP-1	Exendin-4 ;10 ug,sc injection	1,5 nmol/kg,GLP-1 sc injection
GLP-1 9-36amide	Exendin-4 ;10 ug,sc injection	1,5 nmol/kg GLP-1 9-36amide, sc injection
Exendin-4	1,5 nmol/kg,GLP-1 sc injection	Exendin-4 ;10 ug,sc injection
Exendin-4	1,5 nmol/kg GLP-1 9-36amide, sc injection	Exendin-4 ;10 ug,sc injection
isotonic saline	1,5 nmol/kg,GLP-1 sc injection	2 ml of isotonic saline, sc injection
isotonic saline	1,5 nmol/kg GLP-1 9-36amide, sc injection	2 ml of isotonic saline, sc injection
isotonic saline	saline	2 ml of isotonic saline, sc injection

Primary Outcome Measures

Name	Time	Method
blood flow	with in 120 minutes	blood flow change measured by ultra sound

Trial Locations

Locations (1)

Køge Hospital; 🇩🇰 Køge, State..., Denmark