Influence of Tumor Associated Immunity on the Number of Lymph Node Retrieved After Colorectal Cancer Surgery (Preliminary Study)
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 25
- 试验地点
- 1
- 主要终点
- Association between immune related cytokine and number of lymph nodes retrieved.
研究概览
简要总结
Hypothesis of this study is that increased immunity of primary tumor affects the increased number of lymph node retrieved. This study investigates whether immunity-related cytokine expression on primary tumor, colonic mucosa, and serum is associated with the number of lymph node retrieved in colorectal cancer patients.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Cross Sectional
入排标准
- 年龄范围
- 20 Years 至 80 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Histologically confirmed colorectal cancer
- •Non-metastatic cancer (cTNM I, II, or III)
- •Over 20 years of age
- •Curative resection (R0)
排除标准
- •Patient with distant metastasis
- •History of chemotherapy or radiation therapy for malignancy
- •Patient receiving immunosuppressive or anti-inflammatory treatment
- •Hereditory colorectal cancer
- •Preoperative chemoradiation therapy for colorectal cancer
结局指标
主要结局
Association between immune related cytokine and number of lymph nodes retrieved.
时间窗: 2 months after surgery
Immunity related cytokine - IL-12, IFN-r, GM-CSF, IL-4, TNF-a, IL-6, IL-8, IL-10, TGF-b1, CXCR4, SDF1, HGF, VEGF - expression is assessed using Bioplex assay. Patient serum is taken one day before surgery. Primary tumor and colonic mucosal tissue are taken just after surgery. Bioplex assay is performed after patients' enrollment
次要结局
未报告次要终点