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Clinical Trials/NCT00635440
NCT00635440
Completed
Not Applicable

The Effect of Neuromuscular Electrical Stimulation on Muscle Metabolism of Major Abdominal Surgical Patients

Medical University of Vienna1 site in 1 country26 target enrollmentDecember 2005

Overview

Phase
Not Applicable
Intervention
Not specified
Conditions
Muscular Atrophy
Sponsor
Medical University of Vienna
Enrollment
26
Locations
1
Primary Endpoint
mRNA level of IGF-1Ea
Status
Completed
Last Updated
18 years ago

Overview

Brief Summary

Skeletal muscle atrophy is associated with catabolic conditions such as major surgical interventions and leads to reduced muscle strength, increased clinical complications and prolonged convalescence. Several studies revealed immobilisation as a major stimulus for muscle wasting in severely ill patients. This study investigates the potency of neuromuscular electrical stimulation on skeletal muscle growth factors and degradation processes in major abdominal surgery patients.

Registry
clinicaltrials.gov
Start Date
December 2005
End Date
TBD
Last Updated
18 years ago
Study Type
Interventional
Study Design
Crossover
Sex
All

Investigators

Eligibility Criteria

Inclusion Criteria

  • intended for major abdominal surgery
  • more than 18 years old

Exclusion Criteria

  • neuromuscular diseases
  • immobility before surgery
  • arterial occlusive disease Fontaine stadium IV
  • clinical or laboratory signs of inflammation or sepsis
  • diseases of the musculoskeletal systems contraindicating electrical stimulation

Outcomes

Primary Outcomes

mRNA level of IGF-1Ea

Secondary Outcomes

  • mRNA level of MGF, total RNA content, total protein content, ubiquitin conjugated proteins, proteasome activity

Study Sites (1)

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