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临床试验/NCT00635440
NCT00635440已完成不适用

The Effect of Neuromuscular Electrical Stimulation on Muscle Metabolism of Major Abdominal Surgical Patients

Medical University of Vienna2 个研究点 分布在 1 个国家目标入组 26 人开始时间: 2005年12月最近更新:
适应症

试验速览

阶段
不适用
状态
已完成
入组人数
26
试验地点
2
主要终点
mRNA level of IGF-1Ea

研究概览

简要总结

Skeletal muscle atrophy is associated with catabolic conditions such as major surgical interventions and leads to reduced muscle strength, increased clinical complications and prolonged convalescence. Several studies revealed immobilisation as a major stimulus for muscle wasting in severely ill patients. This study investigates the potency of neuromuscular electrical stimulation on skeletal muscle growth factors and degradation processes in major abdominal surgery patients.

研究设计

研究类型
Interventional
分配方式
Randomized
干预模型
Crossover
主要目的
Basic Science
盲法
Single (Investigator)

入排标准

年龄范围
18 Years 至 —(Adult, Older Adult)
性别
All
接受健康志愿者

入选标准

  • intended for major abdominal surgery
  • more than 18 years old

排除标准

  • neuromuscular diseases
  • immobility before surgery
  • arterial occlusive disease Fontaine stadium IV
  • clinical or laboratory signs of inflammation or sepsis
  • diseases of the musculoskeletal systems contraindicating electrical stimulation

结局指标

主要结局

mRNA level of IGF-1Ea

次要结局

  • mRNA level of MGF, total RNA content, total protein content, ubiquitin conjugated proteins, proteasome activity

研究者

申办方类型
Other

研究点 (2)

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