NCT00635440
Completed
Not Applicable
The Effect of Neuromuscular Electrical Stimulation on Muscle Metabolism of Major Abdominal Surgical Patients
ConditionsMuscular Atrophy
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Muscular Atrophy
- Sponsor
- Medical University of Vienna
- Enrollment
- 26
- Locations
- 1
- Primary Endpoint
- mRNA level of IGF-1Ea
- Status
- Completed
- Last Updated
- 18 years ago
Overview
Brief Summary
Skeletal muscle atrophy is associated with catabolic conditions such as major surgical interventions and leads to reduced muscle strength, increased clinical complications and prolonged convalescence. Several studies revealed immobilisation as a major stimulus for muscle wasting in severely ill patients. This study investigates the potency of neuromuscular electrical stimulation on skeletal muscle growth factors and degradation processes in major abdominal surgery patients.
Investigators
Eligibility Criteria
Inclusion Criteria
- •intended for major abdominal surgery
- •more than 18 years old
Exclusion Criteria
- •neuromuscular diseases
- •immobility before surgery
- •arterial occlusive disease Fontaine stadium IV
- •clinical or laboratory signs of inflammation or sepsis
- •diseases of the musculoskeletal systems contraindicating electrical stimulation
Outcomes
Primary Outcomes
mRNA level of IGF-1Ea
Secondary Outcomes
- mRNA level of MGF, total RNA content, total protein content, ubiquitin conjugated proteins, proteasome activity
Study Sites (1)
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