NCT00635440已完成不适用
The Effect of Neuromuscular Electrical Stimulation on Muscle Metabolism of Major Abdominal Surgical Patients
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 26
- 试验地点
- 2
- 主要终点
- mRNA level of IGF-1Ea
研究概览
简要总结
Skeletal muscle atrophy is associated with catabolic conditions such as major surgical interventions and leads to reduced muscle strength, increased clinical complications and prolonged convalescence. Several studies revealed immobilisation as a major stimulus for muscle wasting in severely ill patients. This study investigates the potency of neuromuscular electrical stimulation on skeletal muscle growth factors and degradation processes in major abdominal surgery patients.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Basic Science
- 盲法
- Single (Investigator)
入排标准
- 年龄范围
- 18 Years 至 —(Adult, Older Adult)
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •intended for major abdominal surgery
- •more than 18 years old
排除标准
- •neuromuscular diseases
- •immobility before surgery
- •arterial occlusive disease Fontaine stadium IV
- •clinical or laboratory signs of inflammation or sepsis
- •diseases of the musculoskeletal systems contraindicating electrical stimulation
结局指标
主要结局
mRNA level of IGF-1Ea
次要结局
- mRNA level of MGF, total RNA content, total protein content, ubiquitin conjugated proteins, proteasome activity
研究者
研究点 (2)
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