RBR-3tvjjkx
Recruiting
Phase 2
Treatment of non-motor symptoms of Parkinson's disease with purified extract of Cannabis sativa
Hospital da Clínicas da Faculdade de Medicina da Universidade de São Paulo0 sitesJanuary 25, 2023
Overview
- Phase
- Phase 2
- Intervention
- Not specified
- Conditions
- Parkinson's Disease
- Sponsor
- Hospital da Clínicas da Faculdade de Medicina da Universidade de São Paulo
- Status
- Recruiting
- Last Updated
- 2 years ago
Overview
Brief Summary
No summary available.
Investigators
Eligibility Criteria
Inclusion Criteria
- •Over 25 years of age; Diagnosis of Parkinson's Disease according to Movement Disorder Society criteria; Present pain related to Parkinson's disease according to the criteria of the Parkinson Disease Pain Classification System Questionnaire; Suffer from chronic pain according to the definition of chronic pain recommended by the 11th edition of the International Classification of Diseases; Able to provide informed consent; Have easy access to a telephone
Exclusion Criteria
- •Allergy any component of the studied test solutions;Patients using medications with a narrow therapeutic index, and clinically relevant risk due to significant pharmacological interactions with medication studied; Clinically relevant current liver disease, at the discretion of the investigators, and/or hepatitis C; Concomitant use of valproic acid and/or its derivatives;
- •Personal history of schizophrenia and/or bipolar affective disorder; History of psychotic symptoms not justified by Parkinson's Disease; History of suicidal ideation, planning and/or attempt; Research subjects who will not be able to attend to the trial's follow\-up assessments; Subjects who do not understand Portuguese; Women of childbearing age, unless they are using an Intrauterine Device or had been previously submitted to tubal ligation; Severe non\-compensated psychiatric comorbidities, at the discretion of the researchers; Severe non\-compensated clinical comorbidities, at the discretion of the researchers; Pregnant or breastfeeding women; Use in the past 2 years of Cannabis sp. and/or its derivatives for recreational or therapeutic purposes; Personal history of cannabis use disorder and/or other illicit drugs; Personal history of alcohol, tobacco, opioid, benzodiazepine, barbiturate and/or other substance use disorder
Outcomes
Primary Outcomes
Not specified
Similar Trials
Recruiting
Not Applicable
Clinical observation on the treatment of Parkinson's disease with fatigue by three injectionsParkinson's disease fatigueITMCTR2200006777The First Affiliated Hospital of Guangzhou University of Chinese Medicine
Active, not recruiting
Phase 1
Investigation of the effect of Nabilon in patients suffering from Parkinson´s Disease with non-motor symptoms (e.g.sleeping disorders,cognitive dysfunction, hallucinations, autonomic dysfunction including urinary incontinence, constipation,...)EUCTR2017-000192-86-ATMedizinische Universität Innsbruck, Universitätsklinik für Neurologie48
Active, not recruiting
Phase 1
TREATMENT OF DYSKINESIAS IN PARKINSON’S DISEASE WITH OSU6162 – A PILOT STUDYParkinsons disease is complicated by dyskinesias and dystonia. Due stabilizing properties, we believe (-)-OSU6162 may alleviate dyskinesias, without causing parkinsonism. Aim: To evaluate in a double-blind cross over pilot study whether OSU6162 attenuates dyskinesias without worsening parkinsonism in PD patients with motor complications using clinical examination and patient diaries.EUCTR2009-016360-37-SEBjörn Holmberg8
Active, not recruiting
Phase 1
Investigation of the effect of Nabilon in patients suffering from Parkinson´s Disease with non-Motor symptoms (e.g.sleeping dirsorders, cognitive dysfunction, hallucinations, autonomic dysfunction,...)EUCTR2017-004253-16-ATMedizinische Universität Innsbruck, Universitätsklinik für Neurologie48
Recruiting
Not Applicable
eurofunctional Physical Therapy in Parkinson's disease: a feasibility trialervous system diseases, Pathological conditions, signs and symptoms, Parkinson's disease.RBR-8n94qgniversidade do Estado de Santa Catarina