Effect of Transorbital Electrical STIMulation of Optic Nerve on Remyelination After an Acute Optic Neuritis
试验速览
- 阶段
- 不适用
- 发起方
- 入组人数
- 45
- 试验地点
- 3
- 主要终点
- P100 latency (VEP) after treatment
研究概览
简要总结
In light of experimental models showing that neuronal electrical activity is crucial for the remyelination process, we hypothesize that maintenance of electrical axonal activity in the early stages of optic neuritis may promote myelin repair, limiting thereby axonal degeneration.
In humans, electrical stimulation of the optic nerve has been tested mainly in ischemic neuropathy and retinitis pigmentosa, which are both associated with severe axonal/retinal pathology and poor visual prognosis. In contrast, the inflammation of the optic nerve in optic neuritis is generally transient, with less severe axonal damage at the acute phase, which would allow for better efficacy of electrical stimulation as a strategy to promote remyelination and neuroprotection.In light of experimental models showing that neuronal electrical activity is crucial for the remyelination process, we hypothesize that maintenance of electrical axonal activity in the early stages of optic neuritis may promote myelin repair, limiting thereby axonal degeneration.
In humans, electrical stimulation of the optic nerve has been tested mainly in ischemic neuropathy and retinitis pigmentosa, which are both associated with severe axonal/retinal pathology and poor visual prognosis. In contrast, the inflammation of the optic nerve in optic neuritis is generally transient, with less severe axonal damage at the acute phase, which would allow for better efficacy of electrical stimulation as a strategy to promote remyelination and neuroprotection.
详细描述
This is a randomized, controlled, prospective, interventional, blinded trial which aims to evaluate the safety and efficacy of transorbital electrical nerve stimulation on remyelination and neuroprotection after an acute episode of retrobulbar optic neuritis in patients with multiple sclerosis (MS).
Expected Explorations: The study is composed of 14 visits: a screening/inclusion visit with neurological and ophthalmological evaluation, electrophysiology, MRI and Magnetoencephalography (MEG), 10 transorbital electrical stimulation or sham stimulation visits and finally 3 follow-up visits and evaluations (neurological and ophthalmological). Patient's participation will last 49 weeks (inclusion visit and 48 weeks of follow-up). Participation of healthy volunteers will last one day.
MS patients diagnosed with an optic neuritis will be randomized either in the active arm (transorbital electrical stimulation of the optic nerve - 10 sessions during 2 consecutive weeks) or in the placebo arm (sham stimulation - 10 sessions during 2 consecutive weeks) Expected benefits: Electrical stimulation of the optic nerve after an acute episode of retrobulbar optic neuritis may promote remyelination in the optic nerve and a better long-term visual outcome.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Double (Participant, Outcomes Assessor)
盲法说明
Patients as well as ophthalmologists will be subject to the procedure of masking and will keep the blinding for the duration of the study. As a result, ophthalmologists examiners will not perform electrical stimulation sessions.
The persons in charge of the stimulation will be in "open label" and will ensure the inclusion, the follow-up of the patient throughout the study, the stimulation (SHAM or stimulation), the clinical and neurological examination as well as the collection of the treatments and the notification of the Adverse Events/Serious Adverse Events (AE/SAE).
入排标准
- 年龄范围
- 18 Years 至 60 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •For MS patients:
- •Age between 18 and 60 years old.
- •Relapsing Remitting MS (criteria of McDonald 2017) evolving for less than 10 years or Clinically Isolated Syndrome (CIS)-MS with criteria of spatial dissemination on MRI
- •Subject presenting an acute unilateral episode of optic neuritis treated optimally (bolus of corticosteroids and plasma exchanges if considered necessary)
- •Last medical treatment for optic neuritis received between 30 and 90 days before inclusion
- •Visual acuity <7/10 of the affected eye at the time of inclusion
- •Social security scheme or beneficiary of such a scheme
- •For Healthy Volunteers:
- •Age between 18 and 60 years old.
- •No history of neurological or ophthalmological diseases
- •Corrected visual acuity ≥ 8/10
- •Scheme or beneficiary of such a scheme
排除标准
- •For patients:
- •Differential diagnosis of Optic neuritis:
- •i) Atypical acute optic neuritis (papillitis, severe papilledema, initial optic atrophy) ii) Optic neuromyelitis iii) Normal VEP during the inclusion visit iv) No detection of VEP during the inclusion visit
- •Impossibility to perform MRI, MEG, or electrical stimulation:
- •Pacemaker or neurosensory stimulator or implantable defibrillator Clip on an aneurysm or clip on a vascular malformation of the brain Cochlear implants Ocular or cerebral ferromagnetic foreign bodies Metal prostheses or metal clips or splinters Ventriculoperitoneal neurosurgical bypass valves Permanent makeup of the eyelids or lips Black tattoo, important and close to the cranio-facial sphere. Copper Intrauterine Device Person with proven claustrophobia Epilepsy Brain tumor Intraocular pressure without specific treatment Hypertension without treatment Acute retinal hemorrhage Periorbital skin irritation Significant cognitive deficit Known gadolinium allergy
- •Person with severe or uncontrolled symptoms of kidney, liver, hematological, gastrointestinal, pulmonary or cardiac disease or any uncontrolled intercurrent disease at the time of inclusion.
- •Pregnant or breath-feeding woman.
- •Refusal of the participant to be informed in case of fortuitous discoveries having a direct impact on his health and requiring appropriate care
- •person under judicial protection or deprived of liberty
- •For healthy volunteers:
- •Contraindication to MRI or MEG
- •Person with severe or uncontrolled symptoms of kidney, liver, hematological disease, gastrointestinal, pulmonary or cardiac disease or any uncontrolled intercurrent pathology at the time of inclusion.
- •Pregnant or breath-feeding woman.
- •Refusal of the participant to be informed in case of fortuitous discoveries having a direct impact on his health and requiring appropriate care
- •Person under the protection of justice or deprived of liberty
研究组 & 干预措施
Active Transorbital electrical stimulation
Transorbital electrical stimulation of the optic nerve - 10 sessions during 2 consecutive weeks
干预措施: Transorbital electrical stimulation (Eyetronic Next Wave 1.1) (Device)
Sham Transorbital stimulation
Sham stimulation - 10 sessions during 2 consecutive weeks
干预措施: Transorbital electrical stimulation (Eyetronic Next Wave 1.1) - Sham stimulation (Device)
结局指标
主要结局
P100 latency (VEP) after treatment
时间窗: 24 weeks
Modification of the latency of P100 wave measured by Visual Evoked Potential (VEP) after 24 weeks of treatment with electrical or sham stimulation.
次要结局
- Change of P100 latency and amplitude (VEP) after treatment(12 and 48 weeks)
- Change of mean and temporal Retinal Nerve Fiber Layer (RNFL) thickness and average thickness of macular ganglion cell layer after treatment(12, 24 and 48 weeks)
- Change of P100 amplitude (VEP) after treatment(24 weeks)
- Evolution of macular volume after treatment(12, 24 and 48 weeks)
- Change of mean deflection of visual field 24-2 after treatment(12, 24 and 48 weeks)
- Change of average thickness of macular ganglion cell layer after treatment(12, 24 and 48 weeks)
- Occurrence of adverse events related or not to the stimulation(through study completion, an average of 3 years)