Gut Microbiome and Colorectal Cancer

Completed

• Conditions: Colorectal Cancer

• Registration Number: NCT06748339
• Lead Sponsor: Heliopolis University

Brief Summary

Colorectal cancer (CRC) is reported to be the third leading cause of cancer deaths worldwide, and its prevalence is steadily rising in developing countries. It can be considered a marker of socioeconomic development and a marker of significant changes in food habits and lifestyle. In Egypt, CRC represents the seventh most common cancer. It is the third most reported cancer in males and the fifth most common cancer in females. microbiome dysbiosis may be involved in the pathogensis and thus pose a therapeutic target

Detailed Description

Many reports suggested the role of westernized dietary lifestyles, including high consumption of red meats, animal fats, and cholesterol-rich foods, as well as smoking, decreased physical activity, obesity, diabetes, alcohol consumption, or smoking, in CRC development. These changes in lifestyle are called the external factors, which are now linked to changes in the inner gut microenvironments, mainly the microbiomes. Our aim is to investigate the the changes in microbiome profile in relation to clinical, pathological and lifestyle factors

Study Timeline

• Study Start: 2024-01-01
• Primary Completion: 2024-09-17
• Status Verified: 2024-12
• Study Completion: 2024-12-17
• Study First Submitted: 2024-12-17
• Study First Submitted QC: 2024-12-21
• Last Update Submitted: 2024-12-21
• Study First Posted: 2024-12-27
• Last Update Posted: 2024-12-27

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 18

Inclusion Criteria

• Age of 40 years to 80 years
• Patients with a newly diagnosed CRC

Exclusion Criteria

• Patients with previously known CRC
• Pregnancy or Lactation
• Abdominal surgery within/up to 6 months prior to sample collection
• Antibiotics, corticosteroids, or probiotics up to three months prior to sample collection
• History of other types of cancer
• Subjects on a special diet
• Diabetes, liver, or kidney diseases
• CRC patients who used enema or underwent colonoscopy up to one week before sample collection.

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
The effect of food and lifestyle on microbiome	"through study completion, an average of 1 year"	correlation between food and lifestyle with microbiome profiles
microbiome profile and CRC pathogensis	"through study completion, an average of 1 year"	correlation between microbiome profile and CRC pathogensis

Trial Locations

Locations (1)

cairo university Hopitals (elKasr ELieny ); 🇪🇬 Cairo, Egypt