NCT01869621已完成1 期
The Relation Between Heritability and the Trough Concentration of Metformin in Plasma Under Steady-state in Twins
适应症
干预措施
相关药物
试验速览
- 阶段
- 1 期
- 状态
- 已完成
- 入组人数
- 34
- 试验地点
- 1
- 主要终点
- Heritability
研究概览
简要总结
The trough concentration of metformin will be examined in monozygotic and dizygotic twins. Current twin study will determine the total weight of genetics on the trough concentration of metformin.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Basic Science
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 40 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Age 18-40 years
- •Both twins has to be included
- •Dizygotic twin pairs has to be same sex
- •Informed consent given
- •Healthy condition
排除标准
- •Chronical/daily alcohol abuse
- •Hypersensitivity to metformin
- •Ingestion of drugs containing topiramate or x-ray contrast fluids
- •For women: Positive pregnancy test/breastfeeding at the beginning of the trial. No use of safe anticonceptives
研究组 & 干预措施
Metformin
Experimental
6 days treatment with metformin
干预措施: Metformin (Drug)
结局指标
主要结局
Heritability
时间窗: After 6 days of metformin treatment
The trough concentrations of metformin in twin pairs will be used to determine the effect of heritability on metformin trough concentrations. This will give insight to the weight that genetic factors have on metformin pharmacokinetics at steady-state.
次要结局
- Single nucleotide polymorphisms (SNPs)(After 6 days treatment with metformin)
研究者
Tore B. Stage
MSc Pharm
University of Southern Denmark
研究点 (1)
Loading locations...
相似试验
已完成
不适用
Impact of Genetics on Metformin PharmacokineticsOther Conditions That May Be A Focus of Clinical AttentionNCT00187798University of California, San Francisco24
暂停
不适用
Molecular and Clinical Profile of Diabetes Mellitus and Its ComplicationsObesityDiabetes Mellitus, Type 2Diabetic NephropathyNCT01105858National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)2,310
已完成
1 期
Interaction Between St John's Wort and Metformin?Type 2 DiabetesDepressionNCT01726764University of Southern Denmark20
已完成
不适用
NUtriGenomic Analysis in TwinsMetabolic Response to Dietary ModificationNCT01631123German Institute of Human Nutrition120
进行中（未招募）
4 期
Metabolic Responses of Metformin and Genetic Polymorphisms of SLC22A1 Gene in PCOSPolycystic Ovary SyndromeMetforminNCT05680805Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh100