Visualizing beta cells in patients with a history of gestational diabetes - GLP-1-gestational

ucleaire geneeskunde en radiologie0 个研究点目标入组 24 人开始时间: 待定最近更新: 2024年4月23日

适应症

试验速览

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•Inclusion criteria (women with history of GDM);- Pregnancy with diagnosis of GDM, within the last 5 years;- No other previous pregnancies;- Complete resolution of GDM after delivery (HbA1c in normal range, fasting glucose < 100 mg/dl for at least 1 year in the absence of active pharmacologic therapy or ongoing procedures);- Signed informed consent;Inclusion criteria (women without history of GDM);- Pregnancy without problems in glucose homeostasis, within the last 5 years;- No other previous pregnancies;- No evidence of T2D at time of inclusion (HbA1c in normal range, fasting glucose < 100 mg/dl for at least 1 year in the absence of active pharmacologic therapy);- Insulin secretion-sensitivity index-2 (ISSI-2) >= 800 on oral glucose tolerance test;- Signed informed consent

•Exclusion criteria;- Previous treatment (within 6 months) with synthetic Exendin (Exenatide, Byetta®) or Dipeptidyl-Peptidase IV inhibitors;- Breast feeding;- Current pregnancy or the wish to become pregnant within 6 months;- Renal dysfunction (Calculated creatinine clearance below 40ml/min);- Liver disease defined as aspartate aminotransferase or alanine aminotransferase level of more than three times the upper limit of normal range ;- Age < 18 years;- Incapacitated;- No signed informed consent

发起方

ucleaire geneeskunde en radiologie