Dreaming and EEG Changes During Anaesthesia Maintained With Propofol or Desflurane
Trial Snapshot
- Phase
- Phase 4
- Status
- Completed
- Sponsor
- Melbourne Health
- Enrollment
- 300
- Locations
- 4
- Primary Endpoint
- Incidence of dreaming reported by patients interviewed immediately on emergence from anaesthesia using a standardised questionnaire
Study Overview
Brief Summary
We hypothesise that patients who receive propofol for maintenance of anaesthesia will report dreaming more often when they emerge from anaesthesia than patients who receive desflurane for maintenance of anaesthesia.
Detailed Description
Patients commonly report that they have been dreaming when they emerge from anaesthesia. Data from observational studies and small randomised trials suggests that reports of dreaming are more commonly made after anaesthesia maintained with propofol than anaesthesia maintained with inhaled anaesthetic agents. We propose to randomise 300 healthy patients to receive a standardised general anaesthetic for surgery that includes either propofol or desflurane for maintenance. We will measure the raw and processed electroencephalogram during and after anaesthesia and interview patients about dreaming as soon as they emerge from anaesthesia.
Study Design
- Study Type
- Interventional
- Allocation
- Randomized
- Intervention Model
- Parallel
- Primary Purpose
- Diagnostic
- Masking
- Double (Participant, Outcomes Assessor)
Eligibility Criteria
- Ages
- 18 Years to 50 Years (Adult)
- Sex
- All
- Accepts Healthy Volunteers
- No
Inclusion Criteria
- •Male and female patients
- •Age between 18 and 50 years
- •Presenting for elective surgery under general anaesthesia
Exclusion Criteria
- •Inadequate English language comprehension
- •Major drug abuse problem
Arms & Interventions
1
Propofol based anaesthetic maintenance with propofol effect-site steered target-controlled infusion, in addition to fentanyl and non-opioid analgesics
Intervention: Propofol (Drug)
2
Desflurane based anaesthetic maintenance with manually controlled administration in 100% oxygen in addition to fentanyl and non-opioid analgesics
Intervention: desflurane (Drug)
Outcomes
Primary Outcomes
Incidence of dreaming reported by patients interviewed immediately on emergence from anaesthesia using a standardised questionnaire
Time Frame: recovery room stay
Secondary Outcomes
No secondary outcomes reported