A Comparative Factorial Study Design of Adjuvant Enhanced Ultrasound-Guided Wrist Block Anaesthesia for Hand Surgery : Bupivacane, Dexamethasone, Dexametmiodine
试验速览
- 阶段
- 4 期
- 状态
- 已完成
- 发起方
- 入组人数
- 160
- 试验地点
- 2
- 主要终点
- Comparing the effectiveness of bupivacane alone and bupivacane with dexamethasone and bupivacane with dexametmiodine and bupivacane with dexamethasone and dexametmiodine
研究概览
简要总结
Ultrasound guided wrist block comparing effect of bupivacane alone and bupivacane with dexamethasone and bupivacane with dexametmiodine and bupivacane with dexamethasone and dexametmiodine
详细描述
Ultrasound guided wrist block comparing effect of bupivacane alone and bupivacane with dexamethasone and bupivacane with dexametmiodine and bupivacane with dexametmiodine and dexamethasone.
Taking medical and surgical history from patients. Taking base line data as heart rate and blood pressure and spo2. Measure duration of analgesia for post operative pain using NRS for 24 hours abd recording NRS at time interval of 2 , 4,6,12,24 hours post operative.
Any patient the NRS above 4 will receive 5 mg nalbufin . Recording patients satisfaction by a survey .
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Factorial
- 主要目的
- Prevention
- 盲法
- Triple (Participant, Investigator, Outcomes Assessor)
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •- Patients more than or equal 18 years old and are ASA 1-3
排除标准
- •allergy to used medication
- •pre exist neuropathy
- •coagulapthy
- •cognitive impairment
- •refusal to participate
- •Failed block and requiring general anesthesia
研究组 & 干预措施
Group2: ultrasound guided wrist block with bupivacane.25% and 8mg dexamethasone
Group 2: 40 patients receive ultrasound guided wrist block with 15 ml volume including bupivacane.25% and 8 mg dexamethasone
干预措施: Group 3: ultrasound guided wrist block with bupivacane and dexametmiodine (Procedure)
Group2: ultrasound guided wrist block with bupivacane.25% and 8mg dexamethasone
Group 2: 40 patients receive ultrasound guided wrist block with 15 ml volume including bupivacane.25% and 8 mg dexamethasone
干预措施: Group 4: patients will receive ultrasound guided wrist block with bupivacane and dexamethasone and dexametmiodine (Procedure)
Group 3: ultrasound guided wrist block with bupivacane and dexametmiodine
Group 3: 40 patients receive ultrasound guided wrist block with 15 ml volume totally including bupivacane.25% and 50 mcg dexametmiodine
干预措施: Group 2 : ultrasound guided wrist block with bupivacane and dexamethasone (Procedure)
Group 3: ultrasound guided wrist block with bupivacane and dexametmiodine
Group 3: 40 patients receive ultrasound guided wrist block with 15 ml volume totally including bupivacane.25% and 50 mcg dexametmiodine
干预措施: Group 3: ultrasound guided wrist block with bupivacane and dexametmiodine (Procedure)
Group 4: ultrasound guided wrist block with bupivacane and dexametmiodine and dexamethasone
Group 4 : 40 patients receive ultrasound guided wrist block with 15 ml volume including bupivacane.25% and 8 mg dexamethasone and 50 mcg dexametmiodine
干预措施: Group 3: ultrasound guided wrist block with bupivacane and dexametmiodine (Procedure)
Group 4: ultrasound guided wrist block with bupivacane and dexametmiodine and dexamethasone
Group 4 : 40 patients receive ultrasound guided wrist block with 15 ml volume including bupivacane.25% and 8 mg dexamethasone and 50 mcg dexametmiodine
干预措施: Group 1: ultrasound guided wrist block with bupivacane alone (Procedure)
Group 4: ultrasound guided wrist block with bupivacane and dexametmiodine and dexamethasone
Group 4 : 40 patients receive ultrasound guided wrist block with 15 ml volume including bupivacane.25% and 8 mg dexamethasone and 50 mcg dexametmiodine
干预措施: Group 4: patients will receive ultrasound guided wrist block with bupivacane and dexamethasone and dexametmiodine (Procedure)
Group 3: ultrasound guided wrist block with bupivacane and dexametmiodine
Group 3: 40 patients receive ultrasound guided wrist block with 15 ml volume totally including bupivacane.25% and 50 mcg dexametmiodine
干预措施: Group 1: ultrasound guided wrist block with bupivacane alone (Procedure)
Group 1: ultrasound guided wrist block with bupivacane alone
Group 1: ultrasound guided wrist block with bupivacane.025% .. 15 ml volume totally
干预措施: Group 1: ultrasound guided wrist block with bupivacane alone (Procedure)
Group 1: ultrasound guided wrist block with bupivacane alone
Group 1: ultrasound guided wrist block with bupivacane.025% .. 15 ml volume totally
干预措施: Group 2 : ultrasound guided wrist block with bupivacane and dexamethasone (Procedure)
Group 1: ultrasound guided wrist block with bupivacane alone
Group 1: ultrasound guided wrist block with bupivacane.025% .. 15 ml volume totally
干预措施: Group 3: ultrasound guided wrist block with bupivacane and dexametmiodine (Procedure)
Group 1: ultrasound guided wrist block with bupivacane alone
Group 1: ultrasound guided wrist block with bupivacane.025% .. 15 ml volume totally
干预措施: Group 4: patients will receive ultrasound guided wrist block with bupivacane and dexamethasone and dexametmiodine (Procedure)
Group2: ultrasound guided wrist block with bupivacane.25% and 8mg dexamethasone
Group 2: 40 patients receive ultrasound guided wrist block with 15 ml volume including bupivacane.25% and 8 mg dexamethasone
干预措施: Group 1: ultrasound guided wrist block with bupivacane alone (Procedure)
Group2: ultrasound guided wrist block with bupivacane.25% and 8mg dexamethasone
Group 2: 40 patients receive ultrasound guided wrist block with 15 ml volume including bupivacane.25% and 8 mg dexamethasone
干预措施: Group 2 : ultrasound guided wrist block with bupivacane and dexamethasone (Procedure)
Group 3: ultrasound guided wrist block with bupivacane and dexametmiodine
Group 3: 40 patients receive ultrasound guided wrist block with 15 ml volume totally including bupivacane.25% and 50 mcg dexametmiodine
干预措施: Group 4: patients will receive ultrasound guided wrist block with bupivacane and dexamethasone and dexametmiodine (Procedure)
Group 4: ultrasound guided wrist block with bupivacane and dexametmiodine and dexamethasone
Group 4 : 40 patients receive ultrasound guided wrist block with 15 ml volume including bupivacane.25% and 8 mg dexamethasone and 50 mcg dexametmiodine
干预措施: Group 2 : ultrasound guided wrist block with bupivacane and dexamethasone (Procedure)
结局指标
主要结局
Comparing the effectiveness of bupivacane alone and bupivacane with dexamethasone and bupivacane with dexametmiodine and bupivacane with dexamethasone and dexametmiodine
时间窗: 24 hour
Comparing duration of analgesia by each combination from block administration to first request of analgesia
dexamethasone × dexmedetomidine interaction on duration of postoperative analgesia, defined as the time from completion of the block to the first request for rescue analgesia.
时间窗: defined as the time from block administration to first request of analgesia during the first 24 hour
defined as the time from block administration to first request of analgesia
次要结局
未报告次要终点
研究者
Mahmoud Rafaat Mohamed
Resident doctor
Aswan University