A study to compare Normal Saline and Ringers Lactate for fluid therapy in children with diabetic ketoacidosis
Not Applicable
Completed
- Conditions
- Health Condition 1: E101- Type 1 diabetes mellitus with ketoacidosis
- Registration Number
- CTRI/2019/02/017705
- Lead Sponsor
- Dr Devanshi Singhal
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 50
Inclusion Criteria
Case definition for diabetic ketoacidosis has been taken as random blood glucose more than 200mg/dL, venous pH less than 7.3 or serum bicarbonate less than 15mmol/L and blood ketones more than or equal to 3mmol/L or moderate or large ketonuria
Exclusion Criteria
Children who have received partial treatment or fluid boluses from outside
Children with serum sodium less than 135 mEq/L
Children with serum potassium more than 5.5 mEq/
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Time taken to achieve resolution of acidosis ie pH more than or equal to 7.3 in both groupsTimepoint: Time taken to achieve resolution of acidosis ie pH more than or equal to 7.3 in both groups
- Secondary Outcome Measures
Name Time Method Proportion of patients developing acute renal injuryTimepoint: 48 hours;Time taken for normalization of anion gap and blood glucoseTimepoint: 48 hours;Time taken to change type of fluidTimepoint: 48 hours;Total amount of fluid and insulin administeredTimepoint: 48 hours;Total length of stay in PICUTimepoint: 4 days;Total length of stay in the hospitalTimepoint: 2 weeks