The Potential Role Of MicroRNA-155 And Telomerase Reverse Transcriptase In Diagnosis Of Non-Muscle Invasive Bladder Cancer And Their Pathological Correlation

Not Applicable

Completed

• Conditions: Bladder Cancer; Bladder Disease; Bladder Neoplasm; Micro-RNA
• Interventions: Diagnostic Test: MicroRNAs-155; Diagnostic Test: Human telomerase reverse transcriptase

• Registration Number: NCT03591367
• Lead Sponsor: Mansoura University

Brief Summary

We try to assess the potential role of telomerase reverse transcriptase and MicroRNA (miR-155) in diagnosis of non-muscle-invasive bladder cancer and their correlation with stage and grade of the tumor.

Detailed Description

Not available

Basic Information
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Recruitment & Eligibility
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Study & Design
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Trial Locations

Study Timeline

• Status Verified: 2018-07
• Study First Submitted: 2018-07-08
• Study First Submitted QC: 2018-07-08
• Study First Posted: 2018-07-19
• Study Start: 2018-08-01
• Primary Completion: 2019-05-01
• Study Completion: 2019-05-01
• Last Update Submitted: 2019-11-01
• Last Update Posted: 2019-11-04

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 115

Inclusion Criteria

• Men and women 18 years or older.
• Patient with hematuria suspected to be of bladder origin clinically.
• Willing to be participate in the study.

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Exclusion Criteria

• Patient having another malignancy.
• Hematuria of other causes as trauma and stones

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Study & Design

• Study Type: INTERVENTIONAL
• Study Design: SINGLE_GROUP

Arm && Interventions

Group	Intervention	Description
Hematuria due to suspicious superficial bladder tumor	MicroRNAs-155	MicroRNAs-155 (miRNAs-155) and Human telomerase reverse transcriptase (hTERT)
Hematuria due to suspicious superficial bladder tumor	Human telomerase reverse transcriptase	MicroRNAs-155 (miRNAs-155) and Human telomerase reverse transcriptase (hTERT)

Primary Outcome Measures

Name	Time	Method
sensitivity, specificity and positive and negative predictive values of combined MicroRNA-155 And Telomerase Reverse Transcriptase In diagnosis Of Non-Muscle Invasive Bladder Cancer	1 year	compared by standard final pathological specimen

Secondary Outcome Measures

Name	Time	Method
correlation between serum Vit D and Non-Muscle Invasive Bladder Cancer	1 year	measured serum Vit D in ng/mL.

Trial Locations

Locations (1)

Urology and Nephrology Center; 🇪🇬 Mansourah, Aldakahlia, Egypt