Qualitative Study on Detection & Tx of NSCLC in Pts w/ a History of Alcohol or SUD

Not yet recruiting

• Conditions: Lung Non-Small Cell Carcinoma

• Registration Number: NCT07186699
• Lead Sponsor: University of Southern California

Brief Summary

This study will attempt to identify social facilitators and barriers to detection and treatment of non-small cell lung cancer in order to learn how a history of substance abuse or alcohol use impacts care for non-small cell lung cancer.

Detailed Description

PRIMARY OBJECTIVE:

I. To identify social facilitators and barriers to detection and treatment of NSCLC by interviewing a diverse group of patients at Keck, Los Angeles General Medical Center, and Norris Cancer Center with alcohol or substance use disorder history.

OUTLINE: This is an observational study.

Patients participate in a semi-structured interview and may participate in a follow-up focus group interview in which preliminary findings are shared and feedback is elicited on study.

Study Timeline

• Status Verified: 2025-09
• Study First Submitted: 2025-09-10
• Study First Submitted QC: 2025-09-18
• Study First Posted: 2025-09-22
• Last Update Submitted: 2025-09-23
• Last Update Posted: 2025-09-25
• Study Start: 2025-09-29
• Primary Completion: 2027-09-12
• Study Completion: 2028-09-12

Recruitment & Eligibility

• Status: NOT_YET_RECRUITING
• Sex: All
• Target Recruitment: 45

Inclusion Criteria

• * Adults ≥ 18 years of age

  • Histopathologic or cytologic diagnosis of NSCLC
  • Received or receiving curative intent treatment (e.g. surgery, radiation therapy, systemic therapy)
  • History of alcohol use or substance use disorder (other than tobacco use disorder) within the past 10 years, predating the cancer diagnosis
  • Ability to understand and the willingness to sign a written informed consent
  • English or Spanish speaking. Due to need to conduct semi-structured interviews which can develop into free-flowing conversations we need both participant and interviewer to be fluent

Exclusion Criteria

• Patients with cognitive disability unable to maintain 30-60 minute conversation

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Thematic saturation	Up to 3 years	Will use a Danaher framework to approach analyze interview data using NVivo software (NVivo version 11.0, QSR International). Each interview will be analyzed to identify broad themes.

Trial Locations

Locations (2)

Los Angeles General Medical Center; 🇺🇸 Los Angeles, California, United States

USC / Norris Comprehensive Cancer Center; 🇺🇸 Los Angeles, California, United States