NCT00894231已完成4 期
Levocetirizine Effect on Nasal Nitric Oxide and Nasal Eosinophils in Subjects With Perennial Allergic Rhinitis
AAADRS Clinical Research Center1 个研究点 分布在 1 个国家目标入组 30 人开始时间: 2009年1月最近更新:
适应症
干预措施
相关药物
试验速览
- 阶段
- 4 期
- 状态
- 已完成
- 发起方
- 入组人数
- 30
- 试验地点
- 1
- 主要终点
- The change in objective measure of inflammation nasal NO after LC treatment.
研究概览
简要总结
The purpose of this study is to noninvasively measure the anti-inflammatory effect of levocetirizine after two weeks of treatment in allergic rhinitis subjects.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Treatment
- 盲法
- Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
入排标准
- 年龄范围
- 12 Years 至 65 Years（Child, Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •ICF signed
- •Diagnosis of PAR for 6-12 months greater
- •12 years and older
- •Decreased nasal NO values at baseline
- •Compliance and ability to perform maneuvers and responsibilities
排除标准
- •Oral or systemic steroids for 60 days prior
- •Inhaled, nasal, nebulized steroids w/i 4 weeks
- •Hospitalization or life threatening asthma
- •Use of nasal or oral antihistamines w/i 4 weeks
- •Upper or lower airways infection
- •Direct cigarette smoke exposure
研究组 & 干预措施
placebo
Placebo Comparator
Sugar tablet
干预措施: placebo (Drug)
Xyzal
Active Comparator
干预措施: levocetirizine (Xyzal) (Drug)
结局指标
主要结局
The change in objective measure of inflammation nasal NO after LC treatment.
时间窗: two weeks
次要结局
- The change in nasal eosinophils, QOL and diary scores after LC treatment.(two weeks)
研究者
研究点 (1)
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