MRC Multicentre randomised controlled trial of cognitive behaviour therapy in bipolar affective disorder

Not Applicable

Completed

Conditions: Bipolar affective disorder
Mental and Behavioural Disorders

Registration Number: ISRCTN99884475

Lead Sponsor: Medical Research Council (MRC) (UK)

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Completed

Sex: All

Target Recruitment: 220

Inclusion Criteria

1. Aged 18 years or more
2. Two or more episodes
3. Last episode in previous 12 months
4. Currently/last six months in contact with mental health
5. Currently asymptomatic, depression, hypomania

Exclusion Criteria

1. Cannot engage/ rapid cycling bipolar disorder (more than or equal to four episodes per year)
2. Bipolar disorder secondary to organic cause
3. Mental disorder primarily alcohol or drug related
4. Severe borderline personality disorder
5. Receiving systematic psychological treatment for bipolar disorder
6. Unable to read/write English
7. Unable to give informed consent
8. If the patients referred to the study knew the therapist when the therapist worked in a previous capacity, (e.g. as a community psychiatric nurse in a community mental health team looking after the patient), the patient would not be entered into the study

Study & Design

Study Type: Interventional

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
1. Recurrence of an episode of illness of sufficient severity to reach the Diagnostic and Statistical Manual of mental disorders fourth edition (DSM-IV) criteria for major depressive episode, manic episode or mixed episode, based on the Structured Clinical Interview (SCID)instrument<br>2. A longitudinal severity rating of overall symptom levels for each week since last interview (two months) based on the Longitudinal Interval Follow-up Evaluation (LIFE-II)<br>3. Total costs - data on all services received will be obtained using the Client/Service Receipt Inventory (CSRI; Beecham and Knapp 1992) to cover first the year prior to study entry and then every six months until the end of the follow-up period

Secondary Outcome Measures