NCT05614648终止3 期
A Phase 3, Prospective, Multicenter, Randomized, Double-blind, Sham-controlled Study of the Efficacy and Safety of STX-015 in the Treatment of Pain Associated With Lumbosacral Radiculopathy
适应症
干预措施
相关药物
试验速览
- 阶段
- 3 期
- 状态
- 终止
- 入组人数
- 17
- 试验地点
- 30
- 主要终点
- Primary efficacy: Pain Intensity Difference (PID) for the average pain Numeric Rating Scale (NRS) from baseline to D90 in lumbosacral radiculopathy.
研究概览
简要总结
This study will evaluate the safety and effectiveness of a new pain medication in development, clonidine micropellet. Participants will receive a single injection of either clonidine micropellet or sham injection for the treatment of low back and leg pain from sciatica.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Triple (Participant, Investigator, Outcomes Assessor)
盲法说明
Double-Blinded
入排标准
- 年龄范围
- 18 Years 至 70 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Must be between 18 and 70 years of age (inclusive) at time the Informed Consent Form (ICF) is signed.
- •Must have a primary diagnosis of unilateral lumbar and/or lumbosacral radiculopathy defined by all of the following: supported by history, physical examination, and radiologic pathology consistent with a disc protrusion, non-sequestered extrusion, or sequestered fragment, as evidenced by magnetic resonance imaging (MRI), that is consistent with the clinical signs and symptoms of lumbar or lumbosacral radiculopathy.
- •Subject's pain must have a radicular component (radiation into the leg along the L3-S1 [inclusive] dermatomal pattern) and may or may not be associated with additional neuropathic features such as reduced sensory, motor, or deep tendon reflexes.
- •Worst radicular pain symptoms should be confined to a single dermatomal level as confirmed on physical examination (to allow determination of injection level).
- •The NRS leg pain must be ≥4, must extend below the knee and be consistent with one of the dermatomal distributions noted above.
- •Radicular pain symptoms in the current episode must have been present for at least 8 weeks, but not longer than 9 months at the time of Screening.
- •Subjects must not have had a significant reduction in the pain in the 1 to 2 weeks before Screening (i.e., pain must not be improving significantly based on the discretion of the Investigator).
- •Baseline 0-10 NRS average pain score localized to at least 1 target location must be ≥6 and ≤
- •Subjects must be able to separately distinguish and characterize the contribution of back and leg pain to their overall pain to independently assess the response of each to intervention. Investigators must confirm that subjects can do so based upon pain diagrams and direct questioning.
- •Subjects must have had no significant improvement following a minimum of 8 weeks of the following categories prior to Screening:
- •Mechanical intervention (eg, physical therapy, home exercise program, heat compresses/massage, chiropractic treatment), and
- •Over-the-counter analgesics (non-steroidal anti-inflammatory drugs, topical patches/creams/gels/ointments).
- •Subjects of childbearing potential must have a negative (serum) pregnancy test at Screening and a negative urine pregnancy test within 24 hours before the injection procedure and must commit to either abstain continuously from sexual intercourse or to use, at the Investigator's discretion, highly effective birth control during the study period.
- •Must sign an ICF indicating that they understand the purpose and any risks associated with the procedure required for the study and is willing to participate in the study to completion.
- •Must be willing and able to adhere to the prohibitions and restrictions specified in the protocol.
- •Must be able to read, write, understand, and complete study-related tasks, and adequately communicate regularly with the site.
- •Must have an email address and access to the internet from an electronic device in order to complete daily EDQ information.
排除标准
- •Subject has significant pain unrelated to the lumbar or lumbosacral radiculopathy (eg, knee pain, hip pain, or rib pain) that, in the Investigator's opinion, could require chronic analgesic treatment and interfere with the assessment of IP therapeutic effect.
- •Subject has radiological findings or presenting features such as severe motor weakness (with or without reduced deep tendon reflexes) and is a candidate for surgical referral (i.e., progressive neurologic deficit or cauda equina syndrome).
- •Subject has evidence of pathology on MRI (obtained during the current episode of pain) that may result in pain unlikely to be addressed by the IP, including but not limited to the following:
- •Symptomatic (eg, neurogenic claudication) radiographically confirmed central stenosis at any level or diffuse spine pathology.
- •Non-inflammatory or bony lateral recess or foraminal stenosis such as that caused by facet hypertrophy or osteophytes that is a significant contributor to the current episode of pain.
- •Spondylolisthesis > 3 mm at the level of the involved dermatome.
- •Evidence of a lumbar vertebral compression fracture, synovial cyst, lumbar epidural lipomatosis, or extraforaminal pathology.
- •Subject has a history of, or current diagnosis of, fibromyalgia.
- •Subject has a history of lumbar surgery and/or intradiscal interventions (including discography).
- •Subject has an active infection (eg, fever or other objective evidence of an infection within 7 days of the planned injection) or any skin condition visible at the injection site at time of Screening.
- •Subject has evidence of a coagulation abnormality or history of abnormal bleeding or is on anticoagulation therapy at time of Screening.
- •Subject has current untreated or clinically significant anxiety and/or depression as defined by the following:
- •Beck Anxiety Inventory® (BAI®) score ≥29 or,
- •Beck Depression Inventory-2® (BDI®) score ≥
- •Changes in medications administered for treatment of depression or anxiety within the 30 days before Screening. Note: If a subject is taking antidepressant or anti-anxiety medication, either for the treatment of depression/anxiety or as an analgesic adjunct, the subject must agree to maintain a stable dose (no change in dosage) for the first 3 months of the study.
- •Subject is planning to receive a spinal injection or spine procedure while participating in this study, unless this procedure can be postponed until study completion.
- •Subject has received an ESI, nerve block, or other similar procedure in the lumbosacral area performed during the 8 weeks prior to Screening.
- •Subject is receiving or has received the following medications prohibited in this study:
- •Short-acting opioids taken as needed (PRN) less than 4 days a week (hydrocodone, oxycodone, tramadol, etc.) within 14 days prior to Screening.
- •Long-acting opioids or short-acting opioids taken regularly, i.e., more than 4 days a week within 30 days prior to Screening.
- •Anticonvulsants for treatment of radicular leg pain if the dose has changed in the 30 days prior to Screening or the subject is unable to maintain a stable dose for the first 3 months of the study.
- •Systemic corticosteroids within the 30 days prior to Screening.
- •Central alpha-agents, including clonidine-containing medication or dexmedetomidine within 30 days before Screening.
- •Subject has a history of treatment, or has been recommended for treatment, of alcohol or drug use disorder treatment within the year prior to Screening.
- •Subject has a known or suspected allergy, hypersensitivity, or intolerance to any of the following:
- •Clonidine/clonidine hydrochloride.
- •Polylactic acid (found in products such as Lupron Depot®, Atridox®, some types of dermal fillers, and some types of sutures).
- •Radiographic contrast agents or any other medications to be used during the procedure.
- •Subject has recent (within previous 8 weeks) symptomatic hypotension, orthostatic hypotension, or bradycardia.
- •Subject has a Body Mass Index (BMI) or a body habitus that, in the Investigator's judgment, would require a needle longer than a 3.5-inch Tuohy needle.
- •Subject has participated in a clinical trial of an investigational drug or device within 30 days of Screening.
- •Subject has previously participated in a clinical trial sponsored by Sollis Therapeutics (including Protocol Number STX-015-18-01 and Protocol Number STX-015-18-02).
- •Subject has any medical condition that, in the Investigator's opinion, could adversely impact study participation or safety, require chronic analgesic treatment, or interfere with the pain assessments (eg, painful neuropathy, rheumatologic disorder, etc.).
- •Subject has worker's compensation benefits and/or is involved in any litigation related to his/her radicular pain.
- •Subject is currently pregnant or breast feeding, planning to become pregnant or, if of childbearing potential, is unwilling to have a pregnancy test administered or use appropriate, highly effective contraception.
- •Subject is unable or unwilling to undergo MRI examinations.
- •Subject is unable to adequately rate his/her pain in the EDQ.
- •Presence of active kidney disease, as evidenced by an estimated glomerular filtration rate of less than 60 mL/min/1.73m2 utilizing the Chronic Kidney Disease Epidemiology Collaboration equation.
- •Subjects will be excluded from randomization if they have any of the following during the 7-day Baseline Period:
- •Two or more ratings of NRS Average Leg Pain and/or Back Pain > 9 (showing severe pain),
- •Two or more ratings of NRS Average Leg Pain and/or Back Pain ≥ 9 AND ≤ 3 (showing inconsistent pain).
- •Employees of Sollis Therapeutics, Novotech Health Holdings, or study site personnel directly affiliated with this study, and their immediate family members. Immediate family is defined as a spouse, parent, child, or sibling, whether biological or legally adopted.
研究组 & 干预措施
Clonidine Micropellets Injection
Active Comparator
Clonidine Micropellets single dose injection into the lumbar epidural space
干预措施: Clonidine Micropellets (Drug)
Clonidine Micropellets Injection
Active Comparator
Clonidine Micropellets single dose injection into the lumbar epidural space
干预措施: Tuohy epidural needle (Device)
Sham Insertion
Sham Comparator
Sham Control non-epidural needle placement
干预措施: Tuohy epidural needle (Device)
结局指标
主要结局
Primary efficacy: Pain Intensity Difference (PID) for the average pain Numeric Rating Scale (NRS) from baseline to D90 in lumbosacral radiculopathy.
时间窗: Baseline to day 90
Difference in average pain score, using a scale of 0-10 with 0 no pain and 10 worst possible pain, from baseline to day 90.
Incidence of Treatment-Emergent Adverse Events.
时间窗: Baseline to day 90
Difference in incidence of adverse events and treatment due to radicular leg pain from Baseline to day 90 post injection based on physical examination findings and vital signs measurements.
Incidence of symptomatic hypotension as an adverse event of special interest.
时间窗: Baseline to day 90
Difference in incidence defined as low blood pressure associated with subject-reported symptoms of dizziness, lightheadedness, syncope, blurred vision, or nausea.
次要结局
- Difference in Rescue medication consumption.(Baseline to month12)
- Change in Average and Worst NRS from Day 90 post injection to 12 months post injection.(from Day 90 to month 12 post injection)
- Percent of subjects with significant improvement in pain.(Baseline to day 90)
- Change in Oswestry Disability Index (ODI) score(Baseline to month12)
研究者
研究点 (30)
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