Efficacy of Botulinum Toxin for the Treatment of Dystonia Associated With Parkinson's Disease and Atypical Parkinsonism: a Monocentric Cohort Study With Patient Reported Outcome
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 63
- 试验地点
- 1
- 主要终点
- Comparison of the patient reported efficacy of botulinum toxin treatment between PD and AP patients
研究概览
简要总结
Dystonia is a disabling symptom affecting both patients with idiopathic Parkinson's disease (PD) and atypical parkinsonism (AP).
Botulinum toxinum (BoNT), by blocking muscle contraction, is a possible treatment for focal dystonia.
The benefit of BoNT treatment has been proven in some focal dystonia associated with PD or AP.
The investigators aim to give an overview of the efficacy of BoNT in a variety of focal dystonia in a large cohort of parkinsonian patients.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Retrospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Diagnosed Parkinson's disease or Atypical Parkinsonism
- •Age > 18 years
- •Reported dystonia
- •At least 1 injection with Botulinum toxin realized
排除标准
- •Refusal to participate in the study
结局指标
主要结局
Comparison of the patient reported efficacy of botulinum toxin treatment between PD and AP patients
时间窗: Up to twelve months
Evaluation by the patient of the efficacy of the former injection on an improvement scale ranging from 0 to 100% (minimum value : 0, maximum value : 100, higher scores mean a better outcome) systematically made in routine care during follow up appointment
次要结局
- Comparison of the patient reported duration of improvement after treatment by botulinum toxin between PD and AP patients(Up to twelve months)
研究者
Arnaud Lapostolle
interne
Hospital Avicenne