The efficacy of nail gutter method with topical timolol and topical timolol under occlusion for patients with epidermal growth factor receptor inhibitors induced paronychia: Single-blinded intrapatient randomized controlled study
Phase 2
Recruiting
- Conditions
- Cancer patients aged more than 18 years who received EGFR inhibitors therapy and have more than two paronychia/pyogenic granuloma of finger/nail that affect their everyday life.EGFR inhibitor, PRIDE syndrome, paronychia/pyogenic granuloma
- Registration Number
- TCTR20221026003
- Lead Sponsor
- Faculty of Medicine Siriraj Hospital
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- All
- Target Recruitment
- 56
Inclusion Criteria
1.Cancer patients aged more than 18 years who received EGFR inhibitors therapy
2. Patients have more than two paronychia/pyogenic granuloma of finger/nail (CTCAE paronychia grade 2 and 3) that affect their everyday life.
Exclusion Criteria
Patients with underlining diseases: asthma,COPD, arrhythmia,
Patients who have infected nail that lead to nail extraction.
Patients with neutropenia and thrombocytopenia
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Response 8 weeks after primary intervention Complete response (CR), Partial response (PR), No response score (NR)
- Secondary Outcome Measures
Name Time Method SPOT score ,VAS,CTCAE paronychia grading within 8 weeks after primary intervention Doctor evaluate response