Effect of diet therapy with and without Curcumin in treatment of Polycystic Ovary Syndrome

Not Applicable

• Conditions: Polycystic ovary syndrome.; Polycystic ovarian syndrome; E28.2

• Registration Number: IRCT20200915048731N1
• Lead Sponsor: Yazd University of Medical Sciences

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 27 May 2024

Recruitment & Eligibility

• Status: Complete
• Sex: Female
• Target Recruitment: 96

Inclusion Criteria

Infertile women with PCOS diagnosed according to Rotterdam criteria.
Aged 18–40 years
Candidate for IVF without previous history of IVF
Having a BMI range of 18.5-25 and BMI =25 kg/m²

Exclusion Criteria

Metabolic and endocrine abnormalities including thyroid dysfunction, Cushing's syndrome, diabetes or impaired glucose tolerance, hyperprolactinemia, congenital adrenal hyperplasia, liver disease, cardiovascular disease, kidney disease, hypertension, neurological diseases, any history of mental illness, having cancer, autoimmune and inflammatory disorders (rheumatoid arthritis).
Smoking by the patient or her spouse
Alcohol drinking
Taking contraceptives or any other drugs that may affect reproductive physiology (during the three months before the study)
Taking anti-diabetic, anti-obesity, estrogenic and androgenic drugs
Taking supplements such as vitamin C, vitamin E and omega-3 because of their anti-inflammatory and antioxidant effects, three months before or during the intervention.

Study & Design

• Study Type: interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Interleukin 1 Alpha gene. Timepoint: At the beginning of the study and after 12 weeks of intervention. Method of measurement: Real time Polymerase Chain Reaction (PCR).;5 Alpha reductase gene. Timepoint: At the beginning of the study and after 12 weeks of intervention. Method of measurement: Real time Polymerase Chain Reaction (PCR).