A study on the efficacy of the combination of growth hormone and gonadotropin releasing hormone analogues (GnRHa) on adult height in children with idiopathic short stature.
Completed
- Conditions
- Idiopathic short stature or persistent short stature after being born small for gestational age.
- Registration Number
- NL-OMON23928
- Lead Sponsor
- Pfizer Inc, New York, through Dutch affiliate (Capelle a/d Ijssel) and Ferring (Denmark), through Dutch affiliate (Hoofddorp)
- Brief Summary
J Clin Endocrinol Metab. 2007 Apr;92(4):1402-8. Epub 2007 Feb 6.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 40
Inclusion Criteria
40 adolescents in early puberty, with a height <-2 SDS or with a height SDS between -1 and -2, but a predicted adult height SDS <-2.
Exclusion Criteria
Disorders or medication influencing growth.
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Final height SDS minus initial height SDS.
- Secondary Outcome Measures
Name Time Method 1. Final height SDS; <br /><br>2. Final height SDS minus initial height SDS; <br /><br>3. Final height SDS minus target height; <br /><br>4. Body mass index; <br /><br>5. Bone mineral density; <br /><br>6. Quality of life.