The Glycaemic Response of Local Foods Using the Continuous Glucose Monitoring System

Not Applicable

Completed

• Conditions: Diabetes
• Interventions: Other: High glycemic index; Other: Low glycemic index

• Registration Number: NCT03703544
• Lead Sponsor: Clinical Nutrition Research Centre, Singapore

Brief Summary

This study is carried out to determine the effect of high and low GI of local foods using Continuous Glucose Monitoring System (CGMS™) on 24 hour blood glucose profiles.

Detailed Description

Glycemic Index (GI) is a method of classifying foods based on the food's ability to raise the blood glucose level. Low GI foods are recommended as Participants will have a lower impact on blood glucose concentrations. The research sets out to determine the effect of GI on 24 hour blood glucose profiles in healthy Chinese male participants. There will be two test sessions where participants will consume either a high or low GI breakfast, lunch, snack and dinner. Participants will take part in two test sessions (each spanning over 3 days and to monitor the participants' glycemic response using a Continuous Glucose Monitoring System (CGMS) throughout the period.This study specifically attempts to see how having high and low GI locally consumed meals impact on blood glucose.

Study Timeline

• Study Start: 2017-12-15
• Study First Submitted: 2018-10-09
• Study First Submitted QC: 2018-10-11
• Study First Posted: 2018-10-12
• Status Verified: 2019-05
• Primary Completion: 2020-05-22
• Study Completion: 2020-05-22
• Last Update Submitted: 2020-07-16
• Last Update Posted: 2020-07-17

Recruitment & Eligibility

• Status: COMPLETED
• Sex: Male
• Target Recruitment: 15

Inclusion Criteria

• Chinese, male
• Age between 21-50 years
• Body mass index between 18 to 25 kg/m2
• Normal blood pressure (<140/90 Hgmm)
• Fasting blood glucose < 6 mmol/L

Exclusion Criteria

• Current Smoker
• Have any metabolic diseases (such as diabetes, hypertension etc)
• Have known glucose-6-phosphate dehydrogenase deficiency (G6PD deficiency)
• have medical conditions and/or taking medications known to affect glycaemia (glucocorticoids, thyroid hormones, thiazide diuretics)
• Have an ongoing infection or currently undergoing treatment at the time of screening
• Known Chronic infection or known to suffer from or have previously suffered from or is a carrier of Hepatitis B Virus (HBV), Hepatitis C Virus (HCV), Human Immunodeficiency Virus (HIV)• Have active Tuberculosis (TB) or currently receiving treatment for TB
• Have intolerances or allergies to any foods
• Partake in sports at the competitive and/or endurance levels

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: CROSSOVER

Arm && Interventions

Group	Intervention	Description
High glycemic index	High glycemic index	Subjects will consume locally consumed meals which are high glycemic index for breakfast, lunch snack and dinner will be provided.Participants' blood glucose will be monitored using the Continuous Glucose Monitor.
Low glycemic index	Low glycemic index	Subjects will consume locally consumed meals which are low glycemic index for breakfast, lunch snack and dinner will be provided. Participants' blood glucose will be monitored using the Continuous Glucose Monitor.

Primary Outcome Measures

Name	Time	Method
Daily blood glucose profile	24 hours	The daily total blood glucose response is measured for each low and high GI treatment as the area under the curve over 24 hours using CGMS for breakfast, lunch, snack and dinner.

Trial Locations

Locations (1)

Clinical Nutrition Research Centre; 🇸🇬 Singapore, Singapore