Estimation of Second Cancer Risk in Patients Planned With Different Radiotherapy Regimes for Rectal Cancer - A Planning Study and Model-based Analysis
Trial Snapshot
- Phase
- Not Applicable
- Status
- Completed
- Sponsor
- Enrollment
- 25
- Locations
- 1
- Primary Endpoint
- Calculation of the organ-specific excess lifetime attributable risk (LAR) (%)
Study Overview
Brief Summary
Retrospective study comparing dose distribution of 3D conformal radiotherapy (3DCRT) and volumetric-modulated arc therapy (VMAT) to estimate secondary cancer risk for patients having had radiation therapy for rectal cancer. Twenty-five patients are included in this study. Planning CT scans are used for comparison of dose distribution and calculation of second cancer risk.
Detailed Description
A model-based Analysis calculating the organ-specific excess lifetime attributable risk using the planning CT data sets of 25 patients to estimate second cancer risk for patients after radiotherapy for rectal cancer comparing conventional 3DCRT with VAMT techniques.
Study Design
- Study Type
- Observational
- Time Perspective
- Retrospective
Eligibility Criteria
- Ages
- 18 Years to 100 Years (Adult, Older Adult)
- Sex
- All
- Accepts Healthy Volunteers
- No
Inclusion Criteria
- •Male/Female > 18 years of age
- •pre or postoperative radiation therapy for rectal cancer
- •Planning CT
Exclusion Criteria
- •Planning CT not available
Outcomes
Primary Outcomes
Calculation of the organ-specific excess lifetime attributable risk (LAR) (%)
Time Frame: 60 years (model-based calculation)
LAR is calculated for variable Ages at exposure
Secondary Outcomes
No secondary outcomes reported
Investigators
Daniel Rudolf Zwahlen
MD, MBA
Kantonsspital Graubuenden