Cytokines as predictors on response to preoperative chemoradiotherapy in patients with rectal cancer
- Conditions
- cytokinespredictive valuepreoperative chemoradiotherapyrectal cancerpredictieve waardepreoperatieve chemoradiotherapierectumcarcinoom
- Registration Number
- NL-OMON26782
- Lead Sponsor
- St Antonius Hospital
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Pending
- Sex
- Not specified
- Target Recruitment
- 30
Age ≥18
- Pathohistological diagnosis of locally advanced rectal adenocarcinoma (<15 cm from the anal verge)
- Eligible for preoperative chemoradiotherapy (chemotherapy: oral capecitabine / radiotherapy: 45-50 Gy in total; fractions of 1.8-2 Gy) and surgery (stage 2 or 3 rectal cancer)
- Planned to undergo a venipuncture for a regular blood collection during preoperative CRT, before, and after surgery
- Written informed consent
- Age <18
- Serious adverse events during preoperative chemoradiotherapy
- Use of corticosteroids and/or immunosuppressive drugs during or 1 month prior to the study
- Other malignancies in medical history
- Previous pelvic radiotherapy and/or chemotherapy
- Confirmed bacterial or viral infection during the study or 3 months prior to the study
Study & Design
- Study Type
- Observational non invasive
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Identifying cytokines which can predict response to preoperative chemoradiotherapy in patients with locally advanced rectal cancer.
- Secondary Outcome Measures
Name Time Method