ARISE: After 8 Hours Reperfusion in Ischemic Stroke Embolization
Not Applicable
Suspended
- Conditions
- Ischemic Stroke
- Registration Number
- NCT02533778
- Lead Sponsor
- Abington Memorial Hospital
- Brief Summary
A prospective pilot study to evaluate the recanalization and safety of mechanical thrombectomy through a cerebral angiogram in patients with stroke symptoms last seen normal between 8 - 24 hours.
- Detailed Description
Ischemic stroke patients who are 8-24 hrs from symptom onset without prior mechanical or IV thrombolytic treatment and are screen with CT or MR perfusion imaging showing penumbra and infarction not \> 1/3rd the territory.
Recruitment & Eligibility
- Status
- SUSPENDED
- Sex
- All
- Target Recruitment
- 25
Inclusion Criteria
- Over 18 years last seen normal between 8 - 24 hours, without prior history of intravenous plasminogen activator (IV t-PA ) or
- mechanical thrombectomy Vessels - intracranial vertebral artery, basilar artery, intracranial ICA, ICA terminus bifurcation, MCA M1/M2, or
- ACA NIHSS ≥ 7 MRI DWI/PWI or
- CTA/P, which demonstrates an area of mismatch ≥ 2/3 rd
- Signed informed consent
Exclusion Criteria
- creat >= 2
- NIHSS < 7
- Baseline mRS >= 2
- infarct > 1/3rd MCA territory
- competing trials
- prior IV or IA treatment
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- SINGLE_GROUP
- Primary Outcome Measures
Name Time Method Thrombolysis in Cerebral Infarction (TICI) score 6 months
- Secondary Outcome Measures
Name Time Method National Institutes of Health Stroke Scale (NIHSS) score 6 months Modified Rankin Scale 6 months Montreal Cognitive Assessment (MoCA) tool 6 months
Related Research Topics
Explore scientific publications, clinical data analysis, treatment approaches, and expert-compiled information related to the mechanisms and outcomes of this trial. Click any topic for comprehensive research insights.
What molecular mechanisms underlie mechanical thrombectomy efficacy in ischemic stroke beyond 8 hours?
How does mechanical thrombectomy compare to IV thrombolytics in 8-24 hour ischemic stroke patients with penumbral salvage potential?
Which perfusion-based biomarkers best predict successful recanalization in ARISE trial stroke patients?
What are the long-term safety outcomes of mechanical thrombectomy in extended time window stroke patients?
How do combination approaches of mechanical thrombectomy and neuroprotectants affect reperfusion injury in ischemic stroke?
Trial Locations
- Locations (1)
Abington Memorial Hospital
🇺🇸Abington, Pennsylvania, United States
Abington Memorial Hospital🇺🇸Abington, Pennsylvania, United States