Heat Therapy to Accelerate Muscle Recovery
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- Aspetar
- 入组人数
- 34
- 试验地点
- 2
- 主要终点
- Change in muscle strength after 4 days
研究概览
简要总结
The use of cold on muscle (Ice, Cold Water Immersion - CWI or cryotherapy) is a widespread practice used by health professionals, athletes or non-athletic population in the treatment of muscle soreness and soft tissue injuries. Application of cold on muscle is well known to decrease inflammation and reduce pain perception. However, some studies in humans and animals have reported contrasted effects of cold on muscle regeneration. On the other hand, recent studies in humans suggest that passive heat exposure can impact positively muscle protein synthesis, mitochondrial content and muscle torque in different types of populations. Rodent studies comparing heat and cold modalities following a muscle injury have reported that only repeated heat exposure enhances cross sectional area, accelerate macrophage infiltration in damaged fibers and enhances satellite cells activation which led to a faster muscle regeneration. As such heat therapy may be a promising tool to accelerate recovery after muscle injury. This study will investigate the effect of three distinct thermal interventions (Hot, Cold and Thermoneutral water immersion) on human skeletal muscle regeneration after an eccentric exercise. 36 participants will be distributed in a counterbalanced way into 3 groups being immersed for 15min to 1h per day in either HEAT or COLD or NEUTRAL water for 10 days following eccentric contractions.
详细描述
Background information & study rationale Cold exposure is a therapeutic modality supposed to enhance regeneration by alleviating pain, reducing tissue metabolism and restricting swelling and inflammation process. However, in light of some recent studies in animal models and in humans, cold application on injury might delay and impair muscle regeneration. At the same time, passive heat therapy emerges as a novel powerful strategy to enhance muscle recovery. Indeed, in healthy subjects it has been shown that 1H/day of passive heat exposure during 11 days enhances muscle torque through an improvement in contractile muscle function. In an immobilization context, it was recently reported that repeated passive heat exposure may reduce muscle atrophy and induce mitochondrial adaptations.
In rats, heat exposure following chemically-induced injury has been shown to enhance muscle regeneration by increasing muscle weight and cross-sectional area compared to non-heated or cold exposed rats. Macrophage infiltration were reported to migrate to injury site earlier in heated animals compared to non-heated and icing-treated groups. In the same way, heat exposure was associated with an increase in satellite cells number in injured muscle fibers. In addition, it has been shown that ice application immediately after injury has delayed the recovery of Myosin Heavy Chain (MyHC) profile and in contrast, repeated heat application has facilitated the recovery of an uninjured MyHC profile. Interestingly, collagen fibers area and TGF-β1 (a collagen precursors) were shown to be lower in heated groups than in control and iced groups suggesting less muscle fibrosis. Animal studies suggest that heat exposure may be a potent stimulus to enhance soft tissue regeneration after injury.
Very few human studies have examined the impact of local heat exposure on regeneration after muscle injury. A recent study focusing on muscle regeneration in humans, have investigated the effects of a heat therapy protocol composed of five daily 90 minutes sessions with heating garment performed after an exercise-based injury protocol composed of 300 maximal voluntary eccentric contractions. Compared to thermoneutral intervention, heated group presented a better recovery of strength in a fatigue resistance test consisting of 28 maximal isokinetic contractions at 180°/sec at 1 and 4 days after exercise session.
Study goals and objectives The goal of the present study is to determine the effect of multiple localized hot-water or cold-water immersions on muscle regeneration.
- Principal research question/objective:
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Single (Participant)
入排标准
- 年龄范围
- 18 Years 至 45 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Adult (18 to 45 yrs)
- •Physically active
排除标准
- •Contraindication to physical activity as per the Par-Q questionnaire
- •Neural, skin or muscular pathology.
结局指标
主要结局
Change in muscle strength after 4 days
时间窗: 4 days post exercise
Change in maximal knee extensor isometric voluntary force (kg) 4 days after the exercise as compared to baseline
Change in muscle strength after 2 days
时间窗: 2 days post exercise
Change in maximal knee extensor isometric voluntary force (kg) 2 days after the exercise as compared to baseline
Change in muscle strength after 10 days
时间窗: 10 days post exercise
Change in maximal knee extensor isometric voluntary force (kg) 10 days after the exercise as compared to baseline
次要结局
- Change in muscle fiber(11 days post exercise)