Effect of SSRI and SNRI on various mental activities including learning and problem solving among patients suffering from major depressive disorder
- Conditions
- Health Condition 1: null- All adult diagnosed patients of MDD as per ICD 10 criteria in remission phase
- Registration Number
- CTRI/2018/06/014537
- Lead Sponsor
- Department of Pharmacology IPGMER
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Open to Recruitment
- Sex
- Not specified
- Target Recruitment
- 0
1)Adult patients (18 years to 50 years) of either gender attending psychiatry OPD at IOP,
with a clinical diagnosis of Major Depressive Disorder as per ICD10 criteria.
2)Subjects of MDD must be in remission phase with a Hamilton Depressive Rating Score (HAM-D 17) of <7) at enrolment and taking any of the following SSRIs - fluoxetine, sertraline, escitalopram and/or SNRI like mirtazapine for at least last 6 months. Patients who are additionally on cognitive behavioral therapy (CBT) as part of their treatment shall also be included.
3)Subjects should have at least 8 years of formal school education in order to undertake the cognitive function tests.
4)Subjects or their care givers should be willing to give written informed.
1)History of post traumatic or Obsessive compulsive Disorder (OCD)
2)History of schizophrenia, psychosis or bipolar delusional disorder
3)History of intake of any drugs that are likely to have effect on cognition (anticonvulsants, sedative hypnotics, neuroleptics, opioids)
4)History of addictions- alcohol, substance abuse
Study & Design
- Study Type
- Observational
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Changes in cognitive function scoreTimepoint: Attime points- 3, 6 and 9 months from the date of commencement of study.Both the absolute changes and percentage change from enrollment visit to 9 months visit shall be computed.
- Secondary Outcome Measures
Name Time Method the nature of the changes in different domains of cognitive functions and to analyze whether there are any observable differences in the effects of the individual drugs on cognitive function.Timepoint: At time points- 3, 6 and 9 months from the date of commencement of study.