Compare Celecoxib and Ibuprofen Sr In The Management Of Acute Pain Post Orthopedic Or Gynecological Surgery
Phase 3
Completed
- Conditions
- Pain, Postoperative
- Registration Number
- NCT00150280
- Lead Sponsor
- Pfizer's Upjohn has merged with Mylan to form Viatris Inc.
- Brief Summary
To validate the analgesic efficacy and safety of celecoxib compared with ibuprofen SR in the management of acute pain post orthopedic or gynecological surgery
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 132
Inclusion Criteria
- Undergone uncomplicated orthopedic surgery or abdominal gynecological surgery under epidural anesthesia
- Baseline pain intensity of more than 45 mm as measured by VAS and a severity of pain graded as moderate or severe on the categorical pain intensity scale
Exclusion Criteria
- A previous history of intolerance or hypersensitivity to any NSAIDs, cyclooxygenase inhibitor, sulfonamides, or any analgesic, or to drugs with similar chemical structures
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Primary Outcome Measures
Name Time Method To validate the analgesic efficacy of celecoxib compared with ibuprofen SR in the management of acute pain post orthopedic or gynecological surgery
- Secondary Outcome Measures
Name Time Method To validate safety of celecoxib compared with ibuprofen SR in the management of acute pain post orthopedic or gynecological surgery
Related Research Topics
Explore scientific publications, clinical data analysis, treatment approaches, and expert-compiled information related to the mechanisms and outcomes of this trial. Click any topic for comprehensive research insights.
What are the molecular mechanisms by which celecoxib provides analgesia for postoperative pain?
How does the COX-2 inhibition by celecoxib compare to ibuprofen's COX-1/COX-2 inhibition in postoperative pain management?
What biomarkers could predict patient response to celecoxib versus ibuprofen SR in acute postoperative pain?
What are the potential adverse events associated with long-term use of COX-2 inhibitors like celecoxib in surgical pain management?
Are there combination therapies involving celecoxib or ibuprofen SR that improve postoperative pain outcomes compared to monotherapy?
Trial Locations
- Locations (1)
Pfizer Investigational Site
🇨🇳Shanghai, China
Pfizer Investigational Site🇨🇳Shanghai, China