Prospective observational national multicenter study of community-acquired pneumonia

Not Applicable

Recruiting

• Conditions: Certain infectious and parasitic diseases

• Registration Number: KCT0000327
• Lead Sponsor: Kyungpook National University Hospital

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 11 March 2019

Recruitment & Eligibility

• Status: Recruiting
• Sex: All
• Target Recruitment: 3000

Inclusion Criteria

1. A plain chest X-ray or chest CT performed within 48 hours prior to enrollment, in which there is evidence of new or progressive infiltrate(s), consolidation or pleural effusion consistent with pneumonia

2. Two or more symptoms or sign
- Fever > 38°C with no other cause
- Elevated total peripheral white blood cell count(WBC>12,000 cells/mm3) or leukopenia with a total WBC cell count(WBC<4,000 cells/mm3)
- Altered mental status with no other cause, in > 70 y.o.)
- New onset or worsening cough, or dyspnea, or tachypnea
- New onset of purulent sputum, or change in character of sputum
- Rales or bronchial breath sounds
- PO2 <60 mmHg.(Worsening gas exchange)

Exclusion Criteria

1) Age < 18 years old
2) Nosocomonal pneumonia
3) Patients who have been admitte in hospital for treatment or visited emergency department for more than 72 hours within 2 weeks
4) Patients who have treated with any antibiotics for more than 48 hours
5) Definite pulmonary tuberculosis on initial presentation
6) secondary pneumonia(eg, pulmonary seeding from primary bacteremia)
7) Conditions likely to cause diagnostic confusion or where chest radiograph changes are equivocal
8) Immunocompromised patients
i. Neutropenia, ANC<500/mm3
ii. Leukemia
iii. Lymphoma
iv. Known HIV infection with CD4 count<200/mm3
v. Splenectomy
vi. Those who are in their transplant hospital stay
vii. Cytotoxic chemotherapy
viii. High dose steroids daily for > 2 weeks , >40mg prednisolone, >160mg hydrocortisone, >32mg methylprednisolone, >6mg dexamethasone, or >200mg cortisone
ix. Other immunosuppressives daily for > 2 weeks
9) Patients on antibiotic clinical trials which do not allow being enrolled in this study

Study & Design

• Study Type: Observational Study
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Clinical outcome