Examining the effect of NAC tablet on improving lung problems caused by mustard gas in chemically-wounded patients and veterans

Not Applicable

Conditions: Chronic respiratory disorders caused by chemical weapons (sulfur mustard
mustard gas).
due to inhalation of chemicals, gases, fumes and vapours
J68.4, Y36

Registration Number: IRCT201506181165N5

Lead Sponsor: Research deputy of Baqiyatallah University of Medical Sciences

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Complete

Sex: All

Target Recruitment: 84

Inclusion Criteria

documented exposure to sulfur mustard; documented diagnosis of chronic pulmonary disease due to mustard gas (histological evidence from previous biopsies); no history of tuberculosis; no history of resection of one or more lobes of lung

Exclusion criteria: pneumonia; acute bronchitis; smoking cigarettes; being a substance abuser; any illness in which the medications could not be stopped; occurrence of any severe side effects of N-acetylcysteine (anaphylactoid reaction); use of any kind of antioxidant drugs; deterioration of clinical conditions during the course of the study; consuming less than 80% of allocated NAC medication

Exclusion Criteria

Not provided

Study & Design

Study Type: interventional

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Cough. Timepoint: Before intervention, four months after intervention (end of intervention). Method of measurement: likert scale from 1 to 5: 1=I did not have cough 2=I have cough, but it is not a serious problem 3=I have cough, sometimes disturbs my work 4=I have disturbing cough, usually disturbs my work 5=I have disturbing cough, always disturbs my work.;Dyspnea. Timepoint: Before intervention, four months after intervention (end of intervention). Method of measurement: likert scale from 1 to 5: 1=There is no dyspnea 2=Dyspnea only in extraordinary exercises 3=Dyspnea in ordinary exercise 4=Dyspnea in mild exercise 5=Dyspnea in rest.

Secondary Outcome Measures