A study on the perioperative effect of bupivacaine combined with different doses of hydromorphone under single spinal anesthesia in patients undergoing cesarean section
Phase 4
Completed
- Conditions
- nothing
- Registration Number
- ChiCTR2400088968
- Lead Sponsor
- Ganzhou People's Hospital
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Female
- Target Recruitment
- Not specified
Inclusion Criteria
- Patients with good mental state and no communication barriers, second cesarean section, placental implantation or placenta previa; <br>2. Patients and their families voluntarily sign informed consent forms;<br>3. No history of allergies to opioid and amide local anesthetics
Exclusion Criteria
- psychosis, diabetes, accompanied with neurological diseases; <br>2. Contraindications for spinal anesthesia such as infection and coagulation dysfunction at the puncture site<br>3. Complete placenta previa and emergency events such as rescue during surgery; <br>4. Long term use of analgesic drugs; <br>5. Patients with severe heart, liver, kidney and other functional impairments and a history of bleeding tendency;<br>6. Patients who withdrew from the study midway or did not complete relevant data follow-up statistics, as well as other situations that are not suitable for this study.
Study & Design
- Study Type
- Interventional study
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method The occurrence of adverse reactions such as nausea and vomiting, chest tightness, dyspnea, chills, skin itching, urinary retention, and back discomfort during the operation;;HR, BP, Sp02 during patient anesthesia;The highest anesthesia level for spinal anesthesia.;Incidence of hypotension in patients;Addition frequency of ephedrine;Changes in VAS scores during intraoperative laparotomy (T2), fetal delivery (T3), and suturing (T4);;VAS scores for pain during rest, exercise, and peak pain at 6 hours (T6) and 12 hours (T7) after surgery;;
- Secondary Outcome Measures
Name Time Method Surgical time;Bleeding volume;PCA frequency;Infusion volume; 25/10000 25/1000015Apgar Apgar score at 1 min and 5 min of newborn birth;