Effect of Music Listening on Stress in Acute Stroke

Not Applicable

Active, not recruiting

• Conditions: Acute Stroke
• Interventions: Other: Music listening; Other: Control

• Registration Number: NCT05859841
• Lead Sponsor: Turku University Hospital

Brief Summary

Investigation on changes in the neurochemical stress parameters in acute stroke. 30 patients are recruited in the stroke unit, blood samples are collected at fixed intervals during the first two days. Patients are randomized to music listening and control.Neuropsychological testing is performed in the acute phase and 6 months post-stroke.

Detailed Description

Outcome measures: NIHSS, stress hormone levels, questionnaires on mood and quality of life.

Study Timeline

• Study First Submitted: 2017-06-09
• Study Start: 2017-08-21
• Primary Completion: 2019-06-16
• Status Verified: 2023-05
• Study First Submitted QC: 2023-05-05
• Last Update Submitted: 2023-05-05
• Study First Posted: 2023-05-16
• Last Update Posted: 2023-05-16
• Study Completion: 2023-06-30

Recruitment & Eligibility

• Status: ACTIVE_NOT_RECRUITING
• Sex: All
• Target Recruitment: 32

Inclusion Criteria

• Hemispheric infarction
• Neurologically stable

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Exclusion Criteria

• Previous neurological disease affecting the outcome
• Previous psychiatric disease affecting the outcome
• Substance abuse

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Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Music listening	Music listening	Music listening under instruction by music therapist, min 3 hours daily
Control	Control	Standard treatment, care and rehabilitation

Primary Outcome Measures

Name	Time	Method
Visual Analogue Mood Scale	6 months post-stroke	Change in Visual Analogue Mood Scale scores
Montreal Cognitive Assessment	3 days post-stroke	Montreal Cognitive Assessment score
Blood pressure	3 days post-stroke	Change in systolic/diastolic blood pressure
Stroke and Aphasia Quality of Life scale	6 months post-stroke	Change in Stroke and Aphasia Quality of Life scale score
Montreal Cognition Assessment	6 moths post-stroke	Change in Montreal Cognition Assessment score
Center for Epidemiological Studies Depression score	6 months post-stroke	Change in Center for Epidemiological Studies Depression score
National Institute of Health Stroke Scale	6 months post-stroke	Change in National Institute of Health Stroke Scale
Serum C-reactive protein	2 days post-stroke	Change in serum C-reactive protein level
Pulse rate	3 days post-stroke	Change in pulse rate
Working Memory Questionnaire	6 months post-stroke	Change in Working Memory Questionnaire score
Stroke Impact Scale	6 months post-stroke	Change in Stroke Impact Scale score
Depression, Anxiety and Stress Scale	6 months post-stroke	Change in Depression, Anxiety and Stress Scale scores
Serum cortisol	2 days post-stroke	Change in serum cortisol level

Secondary Outcome Measures

Name	Time	Method
Leisure Activity Questionnaire	6 months post-stroke	Change in leisure activities (pre- vs. post-stroke)

Trial Locations

Locations (1)

Turku University Hospital; 🇫🇮 Turku, Finland