Exposome, Pollutants, Biology in the Older Subject: EXPOSAGE
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 入组人数
- 400
- 试验地点
- 1
- 主要终点
- Frailty (health measure)
研究概览
简要总结
Numerous factors, both individual and environmental, can influence aging, an individual's health, and their functional status. However, the understanding of the combined impact of lifestyle-related exposures (e.g., physical activity, diet, sleep) (personal external exposome), exposures to pollutants (environmental external exposome), and their biological responses (internal exposome)-in other words, the impact of the "exposome" on healthy aging-remains limited, particularly in characterizing the molecular mechanisms associated with these interactions. Exposome approaches identifying key exposures and molecular mechanisms could lead to a better understanding of how the environment, interacting with health behaviors, can affect functional status. Thus, the objective of this study is i) to evaluate the links between the external exposome, the internal exposome and the health of older and aging individuals, and ii) to identify biological markers associated with a vulnerable health status in older and aging individuals.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Other
- 盲法
- None
入排标准
- 年龄范围
- 55 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Aged 55 or over
- •Affiliated with or beneficiaries of a social security scheme
- •Signed the informed consent form •-Persons residing in one of the following municipalities : Antibes, Le Bar-sur-Loup, Berre-les-Alpes, Beuil, Blausasc, Breil-sur-Roya, Cabris, Cannes, Carros, Clans, Contes, Drap, L'Escarène, Escragnolles, Fontan, La Gaude, Gilette, Grasse, Lantosque, Levens, Nice, Peillon, Peymeinade, Saint-André-de-la-Roche, Saint-Etienne-de-Tinée, Sospel, Tourrettes-sur-Loup, Vence, Tende
排除标准
- •patients currently undergoing intensive drug treatment, including chemotherapy
结局指标
主要结局
Frailty (health measure)
时间窗: at baseline and 12 months later
Frailty is assessed using the Groningen Frailty Indicator. The scale comprises 15 items. The total score ranges from 0 to 25, with a higher score being worse.
次要结局
- Smoking habits (external personal exposome measure)(at baseline.)
- Functional and health status(at baseline and 1 year)
- Physical functional capacities (health measure)(at baseline and at 12 months)
- Quality of life (health measure)(at baseline and 12 months)
- Autonomy (health measure)(at baseline and 12 months)
- Comorbidity (health measure)(at baseline and 12 months)
- Pollutant metabolites (internal exposome/biological measure)(at baseline.)
- DNA and telomere damage (internal exposome/biological measure)(at baseline.)
- exposure to air pollutants (external environmental exposome measure)(at baseline)
- exposure to pesticides, hydrocarbons, plastics, flame retardant pollutants (external environmental exposome measure)(at baseline)
- Alcohol habits (external personal exposome measure)(at baseline)
- Self-reported physical activity habits (external personal exposome measure)(at baseline)
- Objective-measured physical activity habits (external personal exposome measure)(at baseline)
- Socioeconomic characteristic (external personal exposome measure)(at baseline)
- Psychological health (external personal exposome measure)(at baseline)