Comparison of the Impact of Saturated Fat From High-fat Yogurt or Low-fat Yogurt and Butter on Cardiometabolic Risk Markers: a Randomized Cross-over Trial
Trial Snapshot
- Phase
- Not Applicable
- Status
- Completed
- Sponsor
- Shahid Beheshti University
- Enrollment
- 30
- Locations
- 1
- Primary Endpoint
- Plasma lipid profile
Study Overview
Brief Summary
The goal of this clinical trial is to compare the effect of saturated fat intake from different source on cardiometabolic risk markers in healthy subjects. The main question it aims to answer are:
-Does intake of saturated fat in the form of high-fat yogurt have a different effect on cardiometabolic risk factors than intake of the same amount from butter? In this study, in two periods of 4 weeks, the effect of receiving saturated fat from high-fat yogurt compared to receiving the same amount of saturated fat from butter and low-fat yogurt on the plasma concentration of lipids, cholesterol, insulin, and some inflammatory factors will be studied in healthy subjects.
Study Design
- Study Type
- Interventional
- Allocation
- Randomized
- Intervention Model
- Crossover
- Primary Purpose
- Prevention
- Masking
- Single (Outcomes Assessor)
Eligibility Criteria
- Ages
- 20 Years to 65 Years (Adult, Older Adult)
- Sex
- All
- Accepts Healthy Volunteers
- Yes
Inclusion Criteria
- •Healthy people who do not use lipid-lowering, blood pressure control or diabetes medications
Exclusion Criteria
- •Taking supplements of omega-3 fatty acids, or antioxidants
Arms & Interventions
High-fat yogurt
Daily consumption of 1-2 servings (based on daily calorie requirement) of high-fat yogurt
Intervention: saturated fat intake (Other)
Low-fat yogurt and butter
Daily consumption of 1-2 servings of low-fat yogurt along with daily consumption of about 10 grams of animal butter
Intervention: saturated fat intake (Other)
Outcomes
Primary Outcomes
Plasma lipid profile
Time Frame: 4 weeks
Plasma concentrations of cholesterol, high-density lipoprotein cholesterol, Low-density lipoprotein cholesterol, and triglyceride
Secondary Outcomes
- Glycemic measures(4 weeks)
Investigators
Javad Nasrollahzadeh
Associate Professor
Shahid Beheshti University