Effects of Buprenorphine on Ulnar Nerve Motor Block
试验速览
- 阶段
- 4 期
- 状态
- 终止
- 入组人数
- 20
- 试验地点
- 2
- 主要终点
- The principal aim of the study is to measure the speed of onset and the time of recovery of motor blockage achieved by lidocaine and buprenorphine
研究概览
简要总结
Recent reports showed that the opioid buprenorphine is a very potent sodium channel blocker. Buprenorphine not only exerts a strong antinociception, but also a long lasting antihyperalgesic effect. This antihyperalgesic effect is not observed for other clinically employed opioids but is common for local anaesthetics.
The principal aim of the study is to compare the speed of onset and the time of recovery of motor blockage achieved by lidocaine and buprenorphine, respectively. The investigators hypothesize that the blocking capacity of buprenorphine is equal to the one of lidocaine.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Basic Science
- 盲法
- Double (Participant, Investigator)
入排标准
- 年龄范围
- 18 Years 至 70 Years（Adult, Older Adult）
- 性别
- Male
- 接受健康志愿者
- 是
入选标准
- •Age: 18 - 65 years
- •Weight: 50-100kg
- •Height: 155-195cm
- •Signed and dated informed consent
- •Sufficient command of German language
排除标准
- •Contraindications to the class of drugs under study
- •Vulnerable subjects (intellectually or mental impaired)
- •Known hypersensitivity to class of drugs or the investigational product
- •Known peripheral neuropathies
- •Diabetes mellitus
- •Chronic alcohol consumption
- •Congestive heart disease
- •Participants of other studies during study period
结局指标
主要结局
The principal aim of the study is to measure the speed of onset and the time of recovery of motor blockage achieved by lidocaine and buprenorphine
时间窗: 6 hours
次要结局
未报告次要终点