Role of Dextrose Prolotherapy and Methyl Prednisolone Injections in Osteoarthritis Knee

Damage of the articularcartilage and laxity of the joint lead to worsening of Osteoarthritis knee. Recently prolotherapy has beenshown to decrease looseness of joints and decrease degeneration of articularcartilage in knee arthritis. However, use of prolotherapy has not been rigorouslystudied in osteoarthritic knee. Only limited studies have been done in westerncountries. There is scarcity of literature inIndian Population. Considering this uncertainty in the use of Dextroseprolotherapy in OA, we propose to conduct this study to find out whetherinjection with Dextrose Prolotherapy improves knee symptoms in patients with OAKnee compared to intra-articular steroid injection. We hypothesize that prolotherapy injections for knee OA willbe equally or more beneficial to the patients than steroids. Thepurpose of this study is to determine whether injectionwith Dextrose Prolotherapy, in and around the knee, can decrease painand disability from knee osteoarthritis. Oursecondary objective is to determine if Dextrose Prolotherapy provide bettersymptom relief than intra-articular Steroid injection.