Effects of Ten-Weeks Resistance Training on Neuromuscular Performance, Heart Rate Variability, Sleep Quality and Mobility in Persons With Multiple Sclerosis
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 36
- 试验地点
- 2
- 主要终点
- Spasticity
研究概览
简要总结
Multiple Sclerosis (ME) is a degenerative, inflammatory and autoimmune demyelinating disease of the central nervous system, characterized by demyelination due to inflammation and degeneration of the myelin sheaths enveloping nerves of the eye, periventricular grey matter, brain, spinal cord and brainstem. The symptoms associated with MS include symptomatic fatigue, muscle weakness, ataxia, mobility and balance problems or cognitive problems. Strength training has been shown to improve strength and mobility in persons with MS.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Supportive Care
- 盲法
- None
入排标准
- 年龄范围
- 20 Years 至 60 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •mild or moderate disability with clinical mild spastic-ataxic gait disorder.
- •stable phase of the disease.
排除标准
- •Expanded Disability Status Scale (EDSS) <
- •relapsing disease within the preceding 12 months.
- •corticosteroid treatment within the last months before study inclusion.
结局指标
主要结局
Spasticity
时间窗: After 10 weeks
Pendulum test
Maximal Voluntary Isometric Contraction of Knee Extension
时间窗: After 10 weeks
Rate of Force Development
时间窗: After 10 weeks
Central Activation Ratio
时间窗: After 10 weeks
次要结局
- Walking speed(After 10 weeks)
- Static balance(After 10 weeks)
- Functional capacity(After 10 weeks)
- Heart Rate Variability(After 10 weeks)
- Sleep Quality(After 10 weeks)
研究者
Jacobo Á. Rubio
Principal Investigator
Universidad Católica San Antonio de Murcia