跳至主要内容
临床试验/CTRI/2025/10/096549
CTRI/2025/10/096549尚未招募Phase 3 4

A Randomized Controlled Study On The Effect Of Valmika Mruttika ( Ant hill soil ) Lepa with Shukrashodhan Mahakashay Churna in Mukhdushika With Special Reference To Acne Vulgaris

Smt K C Ajmera Ayurved Mahavidyalaya Deopur Dhule1 个研究点 分布在 1 个国家目标入组 60 人开始时间: 2025年11月7日最近更新:

试验速览

阶段
Phase 3 4
状态
尚未招募
发起方
入组人数
60
试验地点
1
主要终点
1.Daha (Burning) Decreased

研究概览

简要总结

In the present era, physical appearance carries a very important role as it is one of the factors for a person to be fit. Mukhdushika (Youvan Pidaka) is a burning issue in the society. Though it is not life-threatening, it causes psychological upset of worries to the person. Youvana Pidaka as the name suggests is considered an adolescent disorder. People are more cautious about outer looks and Youvana Pidaka makes one look unattractive. Mukhdushika according to modern science is correlated with Acne vulgaris. Acne is a cutaneous pleomorphic disorder of the Pilo- sebaceous glands involving abnormalities in sebum production and is characterized by the formation of both inflammatory (papules pustules and nodules) and no inflammatory lesions (open and closed come). It typically affects the face but can also occur on the upper arm, trunk & back. 1 According to the Global Burden of Diseases (GBD) study Acne Vulgaris is a very prevalent condition that affects 85% of the population and primarily appears during adolescence. 2 The condition typically begins in adolescence and persists into thirties and forties. 3 In Modern current medical treatment Acne vulgaris includes benzoyl peroxide. Antibiotics, Anti-seborrheic medications, Sulphur and Sodium Sulpha-acetamide, anti-androgen, medications salicylic and hormonal treatments, alpha hydroxy and retinoids, azelaic acid, keratolytic soaps, and nicotinamide. 4 This drug gives temporary relief while causing a variety of adverse effects and Relapse occurs when the medications are discontinued. So, there is a need to find out alternative source. Mukhdushika which has a symptomatic Relationship with Acne vulgaris existed since the Vaidikera. So, in the Ayurvedic text, a detailed description of the management of Mukhdushika has been mentioned. Acharya Sushruta mentioned in one of the 44 Kshudra Rogas there is a formation of Pidaka on the face like Shalmali Kantaka (thorny) called Mukhdushika. 5 Acharya Sharangadhara also described Mukhdushika as Youvana Pidakamala (a waste product)of Shukra Dhatu. 6AsAyurvedas entire clinical approach is centered on the preventative promotional and curative aspect so Ayurveda can provide a better cure for ailment and tackle the underlying causes. That’s why we are considering classical drugs stated in Ayurveda in the treatment of Mukhdushika. According to Aacharya Dalhana Shodhana of disease is done in two ways as follows Antaparimarjan (Internal medication) and Bahiparimarja (external Application) 7 . So here we selected the Valmiki Mruttika (ant hill soil) Lepa for Bahiparimarjan (external Application) as it is very rich in protein that helps in rejuvenating the cells and growth of skin cells. Phenol, antioxidant, and tannins are found to have anti-acne and Varnya properties. Kashaya rasa (Astringent) that acts on Kapha Dosha of Youvana Pidaka 8 and for Antaparimarjan Shukrashodhan Mahakashayaa Churna selected. Because Aacharya Sharngdhara is described as Mukhdushika are Mala of Shukradhatu 9 . So, if proper purification (Shuddhi) of Shukradhatu is done then automatically there will be a decrease in the production of Mala means Mukhdushika. That different way of thinking about Samprapti Bhanga (breakdown of Pathophysiology) is considered here.

研究设计

研究类型
Interventional
分配方式
Randomized
盲法
None

入排标准

年龄范围
18.00 Year(s) 至 30.00 Year(s)(—)
性别
All

入选标准

  • Patients Of Age Group 18 To 30 Years Will Be Selected For Study
  • Both Male And Female Patients Having Sign And Symptoms Of Mukhdushika (Acne Vulgaris) Irrespective Of Their Socioeconomic Status Educational Status Caste And Religion 3.Patient Who Will Fullfill The Diagnostic Criteria Of Mukhdushika.

排除标准

  • 1.K/C/O Prameha pidika(Diabetic carbuncles), Masurika(German Measles), Blisters will be excluded from the current study.
  • 2.Patients who are using topical or systemic steroids or NSAIDs (for example, for pain or skin issues).
  • Clinically infected lesions that require systemic antibiotics, local antiseptics, or additional treatment.
  • Pregnant women or lactating mothers.
  • Known allergic condition.

结局指标

主要结局

1.Daha (Burning) Decreased

时间窗: 14 days

2.Shotha (Imflammation) Decreased

时间窗: 14 days

3. Vedana(Pain) Decreased

时间窗: 14 days

次要结局

  • 1. Number of Pidika present on Nose, Forehead, Chick, Chin, Upper chest, Upper back Decreased(2. Area occupied by Pidika will be measure by Vernier Calliper (nose/forehead/chick/chin/upper chest/upper back) Decreased)

研究者

发起方
Smt K C Ajmera Ayurved Mahavidyalaya Deopur Dhule
申办方类型
Private medical college
责任方
Principal Investigator
主要研究者

Dr Harshal Himmatrao More

Smt K C Ajmera Ayurved Mahavidyalaya Deopur Dhule

研究点 (1)

Loading locations...

相似试验