Attention Bias Modification Treatment for Major Depressive Disorder in Adolescents

Not Applicable

Completed

• Conditions: Major Depressive Disorder, Single Episode, Unspecified

• Registration Number: NCT02078258
• Lead Sponsor: Hunan Normal University

Brief Summary

In this study, we test whether a two-week 8-session neutral attention bias modification (ABM) training and a two-week 4-session positive ABM could reduce depressive symptoms relative to placebo controls in adolescents with major depressive disorder at posttraining and follow-ups during one year.

Detailed Description

Depression is a common health problem in adolescents. Negative attentional bias has been theorized to play a critical role in the onset and maintenance of depression, suggesting that reduction of such biases may treat symptoms of depression. Recent studies have shown that attention bias modification(ABM) training could reduce depressive symptoms in both dysphoria and previously depressed adult patients.To test the effectiveness of ABM training on the treatment of depressive symptoms in depressed adolescents, we designed a randomized, double-blind, placebo controlled trial in adolescents with major depressive disorder(MDD).

Study Timeline

• Study Start: 2012-09
• Primary Completion: 2014-01
• Study First Submitted: 2014-01-14
• Study First Submitted QC: 2014-03-04
• Study First Posted: 2014-03-05
• Study Completion: 2015-07
• Status Verified: 2019-03
• Last Update Submitted: 2019-03-26
• Last Update Posted: 2019-03-28

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 45

Inclusion Criteria

• Meet the major depression disorder's criteria

Exclusion Criteria

• bipolar disorder, schizophrenia or organic mental disorder;
• any concurrent psychotherapy;
• any concurrent psychotropic medication.

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Primary Outcome Measures

Name	Time	Method
Changes in depressive symptom number	baseline, 7-week, 6-month follow-up	Depressive symptom accounts measured by Kiddie Schedule for Affective Disorders and Schizophrenia for School-Age Children.
Changes in depressive severity	baseline, 7-week, 6-month follow-up	depressive severity measured by the construct interview of the Schedule for Affective Disorders and Schizophrenia for School-Age Children(K-SADS)

Secondary Outcome Measures

Name	Time	Method
Diagnostic status of major depressive disorder	baseline, 7-week, 6-month follow-up	Assessed by the diagnostic interview of the Schedule for Affective Disorders and Schizophrenia for School-Age Children
Change of Self-report symptoms	baseline, 7-week, 6-, 12-month follow-up	symptoms measured by the Center for Epidemiological Studies Depression Scale (CES-D), State-Trait Anxiety Inventory-Trait(STAI-T)，Rumination Response Style（RRS)，Suicidal Ideation Questionnaire（SIQ）

Trial Locations

Locations (1)

Department of Psychology, Hunan Normal University; 🇨🇳 Changsha, Hunan, China