Effect Inverse Ratio Ventilation on Arterial Oxygenation and Respiratory Mechanics During lapaLAR

Not Applicable

Completed

• Conditions: Colorectal Neoplasms
• Interventions: Other: inverse IE

• Registration Number: NCT01897584
• Lead Sponsor: Gachon University Gil Medical Center

Brief Summary

Changes of inspiration: expiration ration from 1:2 to 1:1 could improve the arterial oxygenation and respiratory mechanics

Detailed Description

Inverse ratio ventilation already known as effective to improve the oxygenation and respiratory mechanics in the ARDS patients. Recently, there were report of decrease in airway pressure and improve in respiratory compliance during inverse ration ventilation undergoing one lung ventilation. We hypothesized that changes of inspiration and expiration ratio from 1:2 to 1:1 could improve the arterial oxygenation and respiratory mechanics in the patients who undergoing laparoscopic low anterior resection. However, prolonged inspiratory time might compromise cerebral perfusion pressure due to an elevation in central venous pressure and concomitant reductions in mean arterial pressure.

Study Timeline

• Study First Submitted: 2013-06-26
• Study Start: 2013-07
• Study First Submitted QC: 2013-07-09
• Study First Posted: 2013-07-12
• Primary Completion: 2014-12
• Study Completion: 2014-12
• Status Verified: 2015-08
• Last Update Submitted: 2015-08-30
• Last Update Posted: 2015-09-01

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 30

Inclusion Criteria

• colorectal cancer

Exclusion Criteria

• obesity (BMI>35), uncontrolled hypertension, coronary artery disease, uncompensated cardiovascular disease, current respiratory disease, open procedure

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: SINGLE_GROUP

Arm && Interventions

Group	Intervention	Description
Inverse IE	inverse IE	in only one group, inspiration to expiration ratio 1:2 to 1:1 will be applied during pneumoperitoneum

Primary Outcome Measures

Name	Time	Method
arterial oxygenation (PaO2)	baseline PaO2- 2 hour after pneumoperitoneum	sampling for arterial blood from arterial cannular will be analyzed 10 min after anesthetic induction, 20 min after pneumoperitoneum, 40 min after pneumoperitoneum and operation end.

Secondary Outcome Measures

Name	Time	Method
cerebral perfusion pressure	immediately before pneumoperitoneum in the Trendelenburg position, every 5 min up to 20 after I:E ratio 1:1	cerebral perfusion pressure would calculate as mean arterial pressure-central venous pressure from immediately before pneumoperitoneum in the Trendelenburg position, every 5 min up to 20 after I:E ratio 1:1.

Trial Locations

Locations (1)

Kyung Cheon Lee; 🇰🇷 Incheon, Korea, Republic of