Comparison of Daily Versus Weekly Levothyroxine in Hypothyroidism patients
Phase 4
- Conditions
- Health Condition 1: E039- Hypothyroidism, unspecified
- Registration Number
- CTRI/2024/04/065960
- Lead Sponsor
- All India Institute of Medical Sciences Jodhpur
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Open to Recruitment
- Sex
- Not specified
- Target Recruitment
- 0
Inclusion Criteria
1.Known case of Primary Hypothyroidism
2.Patients willing to give written informed consent
Exclusion Criteria
1.Pregnancy and lactating women
2.Patients requiring Levothyroxine dose more than 150 mcg or less than 25 mcg
3.Critical care illness requiring hospitalization in ICU
4.Known cases of pituitary disorders
5.Women currently on Oral Contraceptives Pills or planning to take OCPs
6.Chronic Kidney disease patients with serum creatinine more than 1.8
7.Known cases of nephrotic syndrome
8.All patients diagnosed with Rheumatoid Arthritis
9.Patients with TSH more than 20 milli international unit per liter
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method 1. To compare the change in thyroid hormone (T3, T4, TSH) levels between two groupsTimepoint: Baseline and 12 weeks
- Secondary Outcome Measures
Name Time Method To compare the adverse events between two treatment groupsTimepoint: Baseline and 12 weeks;To compare the laboratory parameters namely LDL, hsCRP, CBC, Urinary protein and NT-pro BNP in two study groups.Timepoint: Baseline and 12 weeks;To compare the mean change in Quality-of-Life scores (SF-36 scaling tool) from baseline to 12 weeks.Timepoint: Baseline and 12 weeks